Lymphokine-Mediated Enhancement of Antibody Formation by Leukemic Cells

  • R. Christopher Butler
  • Jeri M. Frier
  • Herman Friedman
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Infection of susceptible strains of mice with Friend leukemia virus (FLV) results in the development of lymphatic leukemia and focus formation within the spleen. This leukemogenesis is associated with a progressive impairment of immunological responses, including those mediated by both T and B lymphocytes (Notkins et al., 1970). When cultured in vitro the splenocytes from these leukemic mice demonstrate a markedly inhibited ability to respond to antigenic stimulation by sheep erythrocyte (SRBC) antigens (Specter et al., 1976). It has been generally accepted that this impairment is due to the interaction of the virus with antibody-producing B cells or their precursors.


Antibody Response Muramyl Dipeptide Leukemic Mouse Splenocyte Culture Helper Factor 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • R. Christopher Butler
    • 1
  • Jeri M. Frier
    • 1
  • Herman Friedman
    • 2
  1. 1.Departments of Medical Microbiology and ImmunologyArlington HospitalArlingtonUSA
  2. 2.Departments of Medical Microbiology and ImmunologyUniversity of South Florida College of MedicineTampaUSA

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