Lymphokine-Mediated Enhancement of Antibody Formation by Leukemic Cells
Infection of susceptible strains of mice with Friend leukemia virus (FLV) results in the development of lymphatic leukemia and focus formation within the spleen. This leukemogenesis is associated with a progressive impairment of immunological responses, including those mediated by both T and B lymphocytes (Notkins et al., 1970). When cultured in vitro the splenocytes from these leukemic mice demonstrate a markedly inhibited ability to respond to antigenic stimulation by sheep erythrocyte (SRBC) antigens (Specter et al., 1976). It has been generally accepted that this impairment is due to the interaction of the virus with antibody-producing B cells or their precursors.
KeywordsAntibody Response Muramyl Dipeptide Leukemic Mouse Splenocyte Culture Helper Factor
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