Interleukin-3 Production and Action in Tumor-Bearing Hosts

  • Carol J. Burger
  • Klaus D. Elgert
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Examination of the differentiation pathway leading to clonal expansion of cytotoxic T lymphocytes (CTL) has been approached by many methods (Cantor and Boyse, 1975; Gillis et al., 1979; Reinherz et al., 1980). Detection of soluble factors that provide proliferative signals has afforded a new tool for dissecting this pathway. The proposed sequential cascade model, resulting in CTL maturation, begins with the interaction of macrophage (Mφ)-derived interleukin-1 (IL-1) with antigen- or mitogen-primed helper T (Th) cells (Farrar et al., 1980). Th cells then produce both IL-2 (Hancock et al., 1981) and IL-3 (Ihle et al., 1981a). IL-2 stimulates CTL precursor proliferation and immune interferon production which leads to the production of specific, mature CTL (Farrar et al., 1981).


Fresh Cell Splenic Lymphocyte Fibrosarcoma Cell Normal Host Nylon Wool 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Carol J. Burger
    • 1
  • Klaus D. Elgert
    • 1
  1. 1.Department of Biology, Microbiology SectionVirginia Polytechnic Institute and State UniversityBlacksburgUSA

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