Interleukin-3 Production and Action in Tumor-Bearing Hosts
Examination of the differentiation pathway leading to clonal expansion of cytotoxic T lymphocytes (CTL) has been approached by many methods (Cantor and Boyse, 1975; Gillis et al., 1979; Reinherz et al., 1980). Detection of soluble factors that provide proliferative signals has afforded a new tool for dissecting this pathway. The proposed sequential cascade model, resulting in CTL maturation, begins with the interaction of macrophage (Mφ)-derived interleukin-1 (IL-1) with antigen- or mitogen-primed helper T (Th) cells (Farrar et al., 1980). Th cells then produce both IL-2 (Hancock et al., 1981) and IL-3 (Ihle et al., 1981a). IL-2 stimulates CTL precursor proliferation and immune interferon production which leads to the production of specific, mature CTL (Farrar et al., 1981).
KeywordsFresh Cell Splenic Lymphocyte Fibrosarcoma Cell Normal Host Nylon Wool
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