Tumor Growth, Interleukins, and Immune Complexes
Using an antigen-nonspecific assay for circulating immune complexes (PEG-CIC) that detects immune complexes in regions of both antigen and antibody excess, we have shown in our recent studies that changes in serial PEG-CIC levels correlate with changes in tumor volume in a variety of human and animal tumors (Jerry et al., 1976; Rodrick et al., 1983). Furthermore, the elevations in CIC levels were shown to precede decreases in T-cell mitogenic responses to PHA. The precise mechanism of immune modulation in tumor-bearing hosts still remains unclear although regulatory interactions between host immunocytes are undoubtedly involved. As interleukins (IL) play a central role in the mediation and amplification of immune response, and as our earlier data pointed to a temporal relationship between changes in PEG-CIC and tumor growth, we postulated that immune complexes by perturbing intercellular interactions might decrease IL generation.
KeywordsPeripheral Blood Mononuclear Cell Immune Complex Immune Complex Disease Local Tumor Growth Progressive Tumor Growth
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