Role of Thymosin Fraction 5 in Host Defenses to Leukemia in Nutritionally Stressed Mice
Lymphoid cells are continually generated throughout life and are susceptible to changes in nutritional intake. The thymus gland seems to be very sensitive to nutritional stresses which has important consequences for immunoregulation, thymic hormone production, disease resistance, and health (Petro and Watson, 1982). The relationship between nutritional stresses, thymus functions, and immune defenses has recently been reviewed in detail elsewhere (Manderino and Watson, 1984) and is summarized briefly here. Clearly, thymus growth and T-lymphocyte functions can be enhanced or suppressed by high (Watson, 1984) or low (Manderino and Watson, 1983) intakes of various nutrients. For example, high vitamin A or retinoid intakes enhance thymus growth and cellular immune functions (Watson, 1984). The effects and/or role of thymic hormones on these immunological changes is unclear. Therefore, studies of thymosin fraction 5 (TF5) and its effects on resistance to leukemia growth in malnourished mice were undertaken and are detailed herein.
KeywordsMalnourished Child Stressed Mouse Thymus Function Cellular Immune Function Thymic Hormone
Unable to display preview. Download preview PDF.
- Duncan, J. L., Moldawer, L. L., Manderino, G. L., Bistrian, B. R., and Blackburn, G. L., 1984, Terminal transferase in adult malnutrition, Nutr. Res. (in press).Google Scholar
- Manderino, G. L., and Watson, R. R. (eds.), 1984, Role of the thymus gland and thymosin in nutritionally mediated immunosuppression, in: Malnutrition, Disease Resistance and Immune Function, pp. 285–298, Dekker, New York.Google Scholar
- Suskind, R. M., 1977, Malnutrition and the Immune Response, pp. 135–139, Raven Press, New York.Google Scholar
- Watson, R. R. (ed.), 1984, Regulation of immunological resistance to cancer by beta carotene and retinoids, in: Malnutrition, Disease Resistance and Immune Function, pp. 345–355, Dekker, New York.Google Scholar