Efficacy of Thymosin α1 in Animal Models
The thymus gland produces many factors which are known to play a major role in the differentiation and maturation of T cells (Trainin et al., 1983). Considering the importance of T cells in immunoregulatory systems, thymic factors are expected to be useful as pharmaceutical agents to counteract immunodeficiency states. Thymic factors have been given in many clinical instances and shown to improve immunodeficiency diseases, particularly those with congenital T-cell defects (Wara et al., 1975). However, their efficacy in patients with the secondary immunodeficiencies has not been fully investigated.
KeywordsNatural Killer Cell Bone Marrow Cell Spleen Cell Adoptive Transfer Recipient Mouse
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