Interaction of Thymic Hormones with Prostaglandins
Prostaglandins have been implicated as possible mediators of the biological activity of thymic factors. Our recent studies reported that thymic hormones [i.e., thymosin fraction 5(TF5) and thymosin α1] restore lowered thymic functions, such as serum thymic-like activity (STA) and azathioprine (AZ) sensitivity of spontaneous rosette-forming cells (sRFC), when administered to adult thymectomized (ATx) mice (Garaci et al., 1981; Rinaldi-Garaci et al., 1982, 1983a). This effect was completely abolished by indomethacin administration, which is a potent inhibitor of prostaglandin biosynthesis. These data suggested that the action of thymic hormones would require prostaglandin biosynthesis.
KeywordsSplenic Lymphocyte Intact Mouse PGE2 Release Thymic Hormone Indomethacin Administration
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