Interaction of Thymic Hormones with Prostaglandins

  • Enrico Garaci
  • Cartesio Favalli
  • Cristina Rinaldi-Garaci
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Prostaglandins have been implicated as possible mediators of the biological activity of thymic factors. Our recent studies reported that thymic hormones [i.e., thymosin fraction 5(TF5) and thymosin α1] restore lowered thymic functions, such as serum thymic-like activity (STA) and azathioprine (AZ) sensitivity of spontaneous rosette-forming cells (sRFC), when administered to adult thymectomized (ATx) mice (Garaci et al., 1981; Rinaldi-Garaci et al., 1982, 1983a). This effect was completely abolished by indomethacin administration, which is a potent inhibitor of prostaglandin biosynthesis. These data suggested that the action of thymic hormones would require prostaglandin biosynthesis.


Splenic Lymphocyte Intact Mouse PGE2 Release Thymic Hormone Indomethacin Administration 
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  1. Ahmed, A., Wong, D., Thurman, G. B., Low, T. L. K., Goldstein, A. L., Sharkis, S., and Goldschneider, I., 1979, T lymphocyte maturation: Cell surface marker and immune functions induced by lymphocyte cell-free products and thymosin polypeptides, Ann. N.Y. Acad. Sci. 332:81.PubMedCrossRefGoogle Scholar
  2. Favalli, C., Garaci, E., Etheredge, E., Santoro, M. G., and Jaffe, B. M., 1980, Influence of PGE on the immune response in melanoma-bearing mice, J. Immunol. 125:897.PubMedGoogle Scholar
  3. Garaci, E., Del Gobbo, V., Santucci, L., Rossi, G. B., and Rinaldi-Garaci, C., 1979, Changes of serum thymic like factor levels in Friend leukemia virus-infected mice, Leuk. Res. 3:67.PubMedCrossRefGoogle Scholar
  4. Garaci, E., Rinaldi-Garaci, C., Del Gobbo, V., Favalli, C., Santoro, M. G., and Jaffe, B. M., 1981, A synthetic analog of PGE2 is able to induce in vivo theta antigen on spleen cells of adult thymectomized mice, Cell. Immunol. 62:8.PubMedCrossRefGoogle Scholar
  5. Gordon, D. M., Bray, M. A., and Morley, J., 1976, Control of lymphokine secretion by prostaglandin, Nature (London) 262:401.CrossRefGoogle Scholar
  6. Jaffe, B. M., Smith, J. W., Newton, W. T., and Parker, C. W., 1971, Radioimmunoassay for prostaglandins, Science 171:494.PubMedCrossRefGoogle Scholar
  7. Leport, P., Favalli, C., Santoro, M. G., Rinaldi, C., and Jaffe, B. M., 1982, PGE restores the immune response in chemotherapy-treated, tumor-bearing mice, Life Sci. 30:1219.PubMedCrossRefGoogle Scholar
  8. Low, T. L. K., Thurman, G. B., McAdoo, M., McClure, J., Rossio, J. L., Naylor, P. H., and Goldstein, A. L., 1979, The chemistry and biology of thymosin. I. Isolation, characterization and biological activities of thymosin α1 and polypeptide β4 from calf thymus, J. Biol. Chem. 254:981.PubMedGoogle Scholar
  9. Rinaldi-Garaci, C., Del Gobbo, V., Favalli, C., Garaci, E., Bistoni, F., and Jaffe, B. M., 1982, Induction of serum thymic like activity in adult thymectomized mice by a synthetic analog of PGE2, Cell. Immunol. 72:97.PubMedCrossRefGoogle Scholar
  10. Rinaldi-Garaci, C., Garaci, E., Del Gobbo, V., Favalli, C., Jezzi, T., and Goldstein, A. L., 1983a, Modulation of endogenous prostaglandin by thymosin α1 in lymphocytes, Cell. Immunol. 80:57.PubMedCrossRefGoogle Scholar
  11. Rinaldi-Garaci, C., Favalli, C., Del Gobbo, V., Garaci, E., and Jaffe, B. M., 1983b, Is thymosin action mediated by prostaglandin release?, Science 220:1163.PubMedCrossRefGoogle Scholar
  12. Robinson, H. J., Phares, H. F., and Graessle, O. E., 1974, Prostaglandin synthetase inhibitors and infection, in: Prostaglandin Synthetase Inhibitors (H. J. Robinson and J. R. Vane, eds.), Raven Press, New York.Google Scholar
  13. Santoro, M. G., Benedetto, A., and Jaffe, B. M., 1979, Effect of endogenous and exogenous prostaglandin E on Friend erythroleukemia cell growth and differentiation, Br. J. Cancer 39:259.PubMedCrossRefGoogle Scholar
  14. Svedersky, L. P., Hui, A., May, L., McKay, P., and Stebbing, N., 1982, Induction and augmentation of mitogen-induced immune interferon production in human peripheral blood lymphocytes by N-desacetylthymosin α1, Eur. J. Immunol. 12:244.PubMedCrossRefGoogle Scholar
  15. Webb, D. R., Rogers, T. J., and Nowowiejski, 1979, Endogenous Prostaglandin synthesis and the control of lymphocytes function, Ann. N.Y. Acad. Sci. 332:262.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Enrico Garaci
    • 1
  • Cartesio Favalli
    • 1
  • Cristina Rinaldi-Garaci
    • 2
  1. 1.Department of Experimental Medicine2o Rome UniversityRomeItaly
  2. 2.Institute of General Pathology1o Rome UniversityRomeItaly

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