Pituitary Responses to Acute Administration of Thymosin and to Thymectomy in Prepubertal Primates
There is firm clinical and laboratory evidence that adrenal glucocorticoids induce thymic involution, reduce mitotic activity in thymus-dependent (T) lymphocytes, and inhibit phagocytic activity of human leukocytes (Ishidate and Metcalf, 1963; Monjan, 1981). By contrast, low concentrations of glucocorticoids enhance thymocyte differentiation and stimulate antibody formation in vitro (Ambrose, 1964; Ritter, 1977). How this interaction between the hypophyseal-adrenal axis and the immune system is controlled is unclear.
KeywordsLuteinizing Hormone Plasma Cortisol Cortisol Concentration Pituitary Hormone Plasma ACTH
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