Biochemistry of Lymphokine Action on Macrophages
Macrophages (MPs) respond to certain membrane stimulants by a sequence of biochemical reactions known as the oxidative burst (Johnston, 1978). The primary event in the sequence is the reduction of molecular oxygen to superoxide (O 2 - ) catalyzed by a membrane-associated NADPH oxidase. Part of O 2 - is further converted to hydrogen peroxide (H2O2) by enzymatic or spontaneous dismutation.
KeywordsMigration Inhibitory Factor Phorbol Myristate Acetate Oxidative Burst Wheat Germ Agglutinin Peritoneal Exudate Cell
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