Biochemistry of Lymphokine Action on Macrophages

Modulation of Macrophage Superoxide Production by Lymphokine
  • Maya Freund
  • Edgar Pick
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Macrophages (MPs) respond to certain membrane stimulants by a sequence of biochemical reactions known as the oxidative burst (Johnston, 1978). The primary event in the sequence is the reduction of molecular oxygen to superoxide (O 2 - ) catalyzed by a membrane-associated NADPH oxidase. Part of O 2 - is further converted to hydrogen peroxide (H2O2) by enzymatic or spontaneous dismutation.


Migration Inhibitory Factor Phorbol Myristate Acetate Oxidative Burst Wheat Germ Agglutinin Peritoneal Exudate Cell 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Maya Freund
    • 1
  • Edgar Pick
    • 1
  1. 1.Laboratory of Immunopharmacology, Department of Human Microbiology, Sackler Faculty of MedicineTel-Aviv UniversityTel-AvivIsrael

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