Modulatory Interactions between the Central Nervous System and the Immune System

A Role for Thymosin and Lymphokines
  • Nicholas R. Hall
  • Joseph P. McGillis
  • Bryan L. Spangelo
  • George V. Vahouny
  • Allan L. Goldstein
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


The immune system is comprised of varied cell types with diverse characteristics and functions, but which ultimately contribute to the maintenance of host defense. Within the central and peripheral immunological tissues are numerous mechanisms by which immunogenesis and active immunity are regulated. These include direct contact between cells as well as the elaboration of biologically active products. Most of these products have been characterized based on their biological function. Hence, T-cell growth factor, migration inhibitory factor, colony-stimulating factor, as well as a host of others, constitute a long list of growth-promoting or -regulating agents. Thymosin peptides, first isolated from extracted thymic tissue, also play an important immunoregulatory role during the course of T-cell differentiation. These as well as other functions of lymphokines and thymosins are discussed at greater length elsewhere in this volume. However, in addition to the lymphokines and thymic factors which were originally detected and defined during the course of investigations of immune function, hormones that were classically defined within the context of a nonimmunological function can also influence host defense.


Migration Inhibitory Factor Intracerebral Injection Adrenal Weight ACTH Release Ventromedial Nucleus 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Nicholas R. Hall
    • 1
  • Joseph P. McGillis
    • 1
  • Bryan L. Spangelo
    • 1
  • George V. Vahouny
    • 1
  • Allan L. Goldstein
    • 1
  1. 1.Department of BiochemistryThe George Washington University School of Medicine and Health SciencesUSA

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