Abstract
The thymus gland produces numerous polypeptide hormones that can induce T-cell markers and functions in immature cells and, consequently, are considered to be physiologically involved in T-cell differentiation (Bach, 1979). One of these hormones, thymulin, formerly called FTS (for facteur thymique sérique), was initially isolated from porcine serum (Dardenne et al., 1977) but also purified from human serum. Its amino acid sequence was determined (Glu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn) (Pléau et al., 1977) and the synthetic peptide was shown to be fully biologically active (Bach et al., 1977).
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References
Auger, G., Monier, J. C., Dardenne, M., Pléau, J. M., and Bach, J.-F., 1982, Identification of FTS (facteur thymique sérique) on thymus ultrathin sections using monoclonal antibodies, Immunol. Lett. 5:213–216.
Bach, J.-F., 1979, Thymic hormones, Int. J. Immunopharmacol. 1:277–285.
Bach, J.-F., 1983, Thymulin (FTS-Zn), in: Clinics in Immunology and Allergy, Vol. 3, pp. 133–156.
Bach, J.-F., Dardenne, M., Pléau, J. M., and Rosa, J., 1977, Biochemical characterization of a serum thymic factor, Nature (London) 226:55–56.
Bardos, P., and Bach, J.-F., 1983, Modulation of mouse natural killer cell activity by the serum thymic factor (FTS), Scand. J. Immunol. 75:321–325.
Bensman, A., Dardenne, M., Morgant, G., Vasmant, D., and Bach, J.-F., 1983, Decrease of biological activity of serum thymic factor in children with nephrotic syndrome, With Int. Symp. Paediatr. Neurol. p. 59.
Berrih, S., Savino, W., Azoulay, M., and Dardenne, M., 1983, Cultured human epithelial thymic cells as a source of antigen for the production of anti-thymulin monoclonal antibody, Joint Congr. Eur. Soc. (ETCS-Eur. Reticuloendothelial. Soc. (EURES), p. 3.
Blanot, D., Martinez, J., Auger, G., and Bricas, E., 1979, Synthesis of analogs of the serum thymic nonapeptide “facteur thymique sérique” (FTS) (Part I), Int. J. Pept. Protein Res. 14:41–56.
Bricas, E., Martinez, J., Blanot, D., Auger, G., Dardenne, M., Pléau, J. M., and Bach, J.-F., 1977, The serum thymic factor and its synthesis, in: Proceedings, 5th International Peptide Symposium (M. Goodman and J. Meienhofer, eds.), pp. 564–567, Wiley, New York.
Dardenne, M., Pléau, J. M., Man, N. K., and Bach, J.-F., 1977, Structural study of circulating thymic factor: A peptide isolated from pig serum. I. Isolation and purification, J. Biol. Chem. 252:8040–8044.
Dardenne, M., Pléau, J. M., and Bach, J.-F., 1980, Characterization of facteur thymique sérique (FTS) in the thymus. II. Direct demonstration of the presence of FTS in thymosin fraction V, Clin. Exp. Immunol. 42:477–482.
Dardenne, M., Pléau, J. M., Savino, W., and Bach, J.-F., 1982a, Monoclonal antibody against the serum thymic factor (FTS), Immunol. Lett. 4:61–69.
Dardenne, M., Pléau, J. M., Nabarra, B., Lefrancier, P., Derrien, M., and Choay, J., 1982b, Contribution of zinc and other metals to the biological activity of the serum thymic factor (FTS), Proc. Natl. Acad. Sci. USA 79:5370–5375.
Dardenne, M., Savino, W., Wade, S., Kaiserlian, D., Lemonnier, D., and Bach, J.-F., 1984, In vivo and in vitro studies of thymulin in marginally zinc-deficient mice, Eur. J. Immunol. (in press).
Gastinel, L. N., Pléau, J. M., Dardenne, M., and Bach, J.-F., 1984, Characterization of zinc binding sites on the nonapeptide thymulin, Biochim. Biophys. Acta 797:147–155.
Iwata, T., Incefy, G. S., Tanaka, T., Fernandes, G., Menendez-Botet, C. J., Pitt, K., and Good, R. A., 1979, Circulating thymic hormone levels in zinc deficiency, Cell. Immunol. 471:100–105.
Jambon, B., Montagne, P., Bene, M. C., Brayer, M. P., Faure, G., and Bach, J.-F., 1981, Immunohistologic localization of “facteur thymique sérique” (FTS) in human thymic epithelium, J. Immunol. 127:2055–2059.
Kaiserlian, D., and Dardenne, M., 1982, Studies on the mechanisms of the inhibitory effects of serum thymic factor on murine allograft immunity, Cell. Immunol. 66:360–371.
Lacovara, J., and Utermohlen, V., 1983, Isolation and assay of a human plasma factor affecting human thymus-derived lymphocytes, Clin. Immunol. Immunopathol. 27:428–432.
Martinez, J., Blanot, D., Auger, G., Sasaki, A., and Bricas, E., 1980, Synthesis of analogs of the serum thymic nonapeptide “facteur thymique sérique” (FTS), Part II, Int. J. Pept. Protein Res. 16:267–279.
Monier, J. C., Dardenne, M., Pléau, J. M., Deschaux, P., and Bach, J.-F., 1980, Characterization of facteur thymique sérique (FTS) in the thymus. I. Fixation of anti-FTS antibodies on thymic reticuloepithelial cells, Clin. Exp. Immunol. 42:470–476.
Pléau, J. M., Dardenne, M., Blouquit, Y., and Bach, J.-F., 1977, Structural study of circulating thymic factor: A peptide isolated from pig serum. II. Amino acid sequence, J. Biol. Chem. 252:8045–8047.
Pléau, J. M., Dardenne, M., Blanot, D., Bricas, E., and Bach, J.-F., 1979, Antagonistic analogue of serum thymic factor (FTS) interacting with the FTS cellular receptor, Immunol. Lett. 12:179–182.
Savino, W., Dardenne, M., Papiernik, M., and Bach, J. F., 1982, Thymic hormone-containing cells: Characterization and localization of serum thymic factor in young mouse thymus studied by monoclonal antibodies, J. Exp. Med. 156:628–634.
Savino, W., Dardenne, M., Benin, S., and Bach, J. F., 1984, Evidence for zinc dependent antibody binding sites in the molecule of thymulin, a thymic hormone: A study using antithymulin monoclonal antibodies, submitted for publication.
Strachan, R. G., Paleveda, W. J., Bergstrand, S. J., Nutt, R. F., Holly, F. W., and Veber, D. I., 1979, Synthesis of a proposed thymic factor, J. Med. Chem. 22:586–588.
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© 1984 Plenum Press, New York
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Dardenne, M., Savino, W., Gastinel, L., Bach, JF. (1984). Thymulin. In: Goldstein, A.L. (eds) Thymic Hormones and Lymphokines. GWUMC Department of Biochemistry Annual Spring Symposia. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4745-3_3
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DOI: https://doi.org/10.1007/978-1-4684-4745-3_3
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