Lymphocyte Proliferation, Lymphokine Production, and Lymphocyte Receptors in Aging

  • A. L. De Weck
  • F. Kristensen
  • F. Joncourt
  • F. Bettens
  • G. D. Bonnard
  • Y. Wang
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


Lymphocyte proliferation is one of the basic functions of the immune system, since it appears required as well for the acquisition of immunological memory as for clonal expansion of specific lymphocyte populations. In recent years, the combination of several techniques, such as analysis of the cell cycle by cytofluorometry (Darzinkiewicz et al., 1976; Stadler et al., 1980), measurement of [3H]-TdR uptake, detection of membrane receptors by immunofluorescence or ligand binding (Munck and Vira, 1975), and quantitative assessment of various lymphokines produced by proliferating lymphoid cells, has permitted the establishment of an integrated picture of the various events associated with the proliferation of lymphocytes. Although this picture is still fragmentary, the analysis of lymphocyte functions which it makes possible has already been found relevant and informative in several clinical situations, where a dysregulation of lymphocyte functions is apparent. The purpose of this paper is to review briefly the current possibilities to analyze lymphocyte proliferation in clinical situations and their application to the aging process.


Lymphocyte Proliferation Human Peripheral Blood Lymphocyte Thymic Hormone Lymphocyte Receptor Murine Spleen Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • A. L. De Weck
    • 1
  • F. Kristensen
    • 1
  • F. Joncourt
    • 1
  • F. Bettens
    • 1
  • G. D. Bonnard
    • 1
  • Y. Wang
    • 1
  1. 1.Institute for Clinical Immunology, InselspitalUniversity of BernBernSwitzerland

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