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T-Cell Growth Factor

Purification, Interaction with a Cellular Receptor, and in Vitro Synthesis
  • Richard J. Robb
  • Yuan Lin
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

T-cell growth factor (TCGF), also known as interleukin-2, is a small glycoprotein which provides a necessary signal for the proliferation of activated T cells (Morgan et al., 1976; Gillis and Smith, 1977). The factor is released by T cells in response to antigen or lectin stimulation and requires the action of a second, macrophage-derived lymphokine, termed interleukin-1, for its production (Smith et al., 1980). Although the bioactivity of TCGF is antigen-nonspecific and often crosses species lines, specificity of the immune response is maintained by the requirement that a responding T cell be specifically activated before it expresses receptors for the growth factor (Bonnard et al., 1979; Larsson, 1981).

Keywords

JURKAT Cell Phorbol Myristate Acetate Phorbol Myristate Acetate Immunoaffinity Purification Affinity Support 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Richard J. Robb
    • 1
  • Yuan Lin
    • 1
  1. 1.Central Research and Development DepartmentE. I. du Pont de Nemours and Company, Glenolden LaboratoryGlenoldenUSA

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