T-Cell Growth Factor

Purification, Interaction with a Cellular Receptor, and in Vitro Synthesis
  • Richard J. Robb
  • Yuan Lin
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)


T-cell growth factor (TCGF), also known as interleukin-2, is a small glycoprotein which provides a necessary signal for the proliferation of activated T cells (Morgan et al., 1976; Gillis and Smith, 1977). The factor is released by T cells in response to antigen or lectin stimulation and requires the action of a second, macrophage-derived lymphokine, termed interleukin-1, for its production (Smith et al., 1980). Although the bioactivity of TCGF is antigen-nonspecific and often crosses species lines, specificity of the immune response is maintained by the requirement that a responding T cell be specifically activated before it expresses receptors for the growth factor (Bonnard et al., 1979; Larsson, 1981).


JURKAT Cell Phorbol Myristate Acetate Phorbol Myristate Acetate Immunoaffinity Purification Affinity Support 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Richard J. Robb
    • 1
  • Yuan Lin
    • 1
  1. 1.Central Research and Development DepartmentE. I. du Pont de Nemours and Company, Glenolden LaboratoryGlenoldenUSA

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