T-Cell Growth Factor
T-cell growth factor (TCGF), also known as interleukin-2, is a small glycoprotein which provides a necessary signal for the proliferation of activated T cells (Morgan et al., 1976; Gillis and Smith, 1977). The factor is released by T cells in response to antigen or lectin stimulation and requires the action of a second, macrophage-derived lymphokine, termed interleukin-1, for its production (Smith et al., 1980). Although the bioactivity of TCGF is antigen-nonspecific and often crosses species lines, specificity of the immune response is maintained by the requirement that a responding T cell be specifically activated before it expresses receptors for the growth factor (Bonnard et al., 1979; Larsson, 1981).
KeywordsJURKAT Cell Phorbol Myristate Acetate Phorbol Myristate Acetate Immunoaffinity Purification Affinity Support
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