The Use of Lymphoid Cells Expanded in IL-2 for the Adoptive Immunotherapy of Murine and Human Tumors
The adoptive immunotherapy of cancer refers to the transfer, to the tumor-bearing host, of immunologically competent cells capable of mediating responses against tumor. Specific adoptive immunotherapy is a theoretically attractive approach to the treatment of tumors although few examples exist of the effective treatment of established syngeneic solid tumors using this modality. Early reports from Delorme and Alexander (1964) claimed that thoracic duct lymphocytes from immunized rats as well as lymphocytes from immunized xenogeneic animals (Alexander et al., 1966) could mediate the regression of solid methylcholanthrene-induced sarcomas. Borberg et al. (1972) treated mice bearing the Meth-A sarcoma with up to 4 × 109 immunized syngeneic lymphocytes and succeeded in causing the regression of established tumors. Using the Meth-A tumor, but an alternative method of immunization, Berendt and North (1980) have demonstrated that the intravenous infusion of sensitized T cells from immune donors could cause complete regression of established tumors growing in a T-deficient host. They also showed that infusion of splenocytes from tumor-bearing donors could inhibit this regression, suggesting that suppressor T cells existed in the tumor-bearing host. Fernandez-Cruz et al. (1980) showed that intravenous infusion of immune lymphocytes was capable of curing rats bearing a subcutaneous tumor, and Smith et al. (1977) showed that immunized peritoneal exudate cells from syngeneic guinea pigs were capable of curing guinea pigs with established line 10 hepatoma.
KeywordsToxicity Lymphoma Penicillin Sarcoma Streptomycin
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