Characterization of Immunoaffinity-Purified Human T-Cell Growth Factor from JURKAT Cells
T-cell growth factor (TCGF) is a lymphokine that was first identified in conditioned media of mitogen-activated human T-cell culture (Morgan et al., 1976). TCGF also occurs in other mammalian systems and its biological properties were recently reviewed (Smith, 1983). TCGF proved to be essential for the isolation of human T-cell leukemia virus. For a recent review see Gallo and Wong-Staal (1982).
KeywordsJURKAT Cell Bovine Leukemia Virus Intact Protein Acetonitrile Concentration Nucleic Acid Binding Protein
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- Clark, S. C., Arya, S. K., Wong-Staal, F., Matsumoto-Kobayashi, M., Kay, R. M., Kaufman, R. J., Brown, E. L., Shoemaker, C., Copeland, T., Oroszlan, S., Smith, K., Sarngadharan, M. G., Lindner, S. G., and Gallo, R. C., 1984, Human T-cell growth factor: Partial amino acid sequence, cDNA cloning, and organization and expression in normal and leukemic cells, Proc. Natl. Acad. Sci. USA (in press).Google Scholar