Thymosin β4 Is Present in a Subset of Oligodendrocytes in the Normal Human Brain
Thymosin β4, a polypeptide extracted from the original thymosin fraction 5 (Hopper et al., 1975), has been characterized, sequenced, and synthesized (Low and Goldstein, 1981, 1982). Thymosin β4 affects the early stages of T-cell differentiation, has a MIF-like activity (Low and Goldstein, 1981), and may play a role in cellular immune mechanisms (Hannappel et al., 1982). It has been found in a variety of rat and mouse tissue extracts including spleen, thymus, brain, liver, and peritoneal macrophages (Hannappel et al., 1982), but its cellular distribution and presence in human tissues are unknown.
KeywordsPeritoneal Macrophage Thymic Epithelial Cell Human Thymus Thymic Hormone Interdigitating Reticular Cell
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