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Human Peripheral Blood Lymphocytes Bear Markers for Thymosins (α1, α7, β4)

  • Marinos C. Dalakas
  • David L. Madden
  • Aurella Krezlewicz
  • John L. Sever
  • Allan L. Goldstein
Part of the GWUMC Department of Biochemistry Annual Spring Symposia book series (GWUN)

Abstract

Within a partially purified calf thymic extract termed thymosin fraction 5 (Goldstein et al., 1972), there exist several active polypeptides with distinct immunobiological action (Trivers and Goldstein, 1980; Low and Goldstein, 1982). Among those, thymosin α1 affects the early stages of T-lymphocyte maturation and induces helper T cells; thymosin α7 affects the induction of suppressor T-cell development (Trivers and Goldstein, 1980); and thymosin β4 affects the maturation of prothymocytes and has a MIF-like activity (Low and Goldstein, 1982).

Keywords

Peripheral Blood Lymphocyte Normal Rabbit Serum Thymic Epithelial Cell Human Peripheral Blood Lymphocyte Human Thymus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Marinos C. Dalakas
    • 1
  • David L. Madden
    • 1
  • Aurella Krezlewicz
    • 1
  • John L. Sever
    • 1
  • Allan L. Goldstein
    • 2
  1. 1.National Institute of Neurological and Communicative Disorders and StrokeNational Institutes of HealthBethesdaUSA
  2. 2.Department of BiochemistryThe George Washington University School of Medicine and Health SciencesUSA

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