Synthetic Small Thymic Peptides
In 1976 we had started to collect human thymic tissue for the isolation and structural elucidation of immunoregulatory proteins. Specialized in protein chemistry and peptide synthesis (Birr, 1978, 1980), however, we immediately initiated the total synthesis of thymosin α1 when the sequence of this polypeptide consisting of 28 amino acid residues was published in 1977 (Goldstein et al.). Our methodological know-how in the synthesis of polypeptides rich in trifunctional amino acids furnished the total synthesis in solution of thymosin α1 within 2 years (Birr and Stollenwerk, 1979) including one less successful trial for the synthesis of the polypeptide.
KeywordsTotal Synthesis Mixed Lymphocyte Culture Performic Acid Immunoregulatory Property Thymic Peptide
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