Structural Correlates of Idiotypes Expressed on Galactan-Binding Antibodies

  • Stuart Rudikoff


Antigenic determinants located on the variable region of the immunoglobulins (now commonly referred to as idiotypes) were originally described in humans in 1955(1) and in rabbits in 1963.(2) These markers have proven to be extremely valuable in the study of immunoglobulin genetics, diversity, and structure-function relationships. More recently, interest in idiotypes has expanded with the proposal of Jerne(3) suggesting that the determinants expressed on a given antibody population (Abl) are recognized by a second set of antibodies (Ab2 or anti-idiotype) which may in turn be recognized by additional sets of antibodies (Ab3, Ab4, etc.) forming a network which is postulated to be intimately involved in the regulation of immune responses.


Antigenic Determinant Immunize Protein CDR3 Region Myeloma Protein CDR3 Sequence 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Stuart Rudikoff
    • 1
  1. 1.Laboratory of GeneticsNational Cancer InstituteBethesdaUSA

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