Differential Expression of Igh-1-Linked T-Cell Alloantigens

Antigen Receptors or Evolutionary Rudiments of Immunoglobulin Genes?
  • Frances L. Owen


The relationship between antigen receptors on T and B cells has long been debated(1–3) Immunoglobulin on the surface of B cells clearly acts as an antigen recognition structure(4) and may also be a key to the differentiation of an IgM-bearing early B cell(5) to a cell population expressing both IgM and IgD.(6–7) T- and B-cell receptors may closely resemble one another in that at least part of the polypeptide chain coding for antigenic specificity of each cell type carries determinants cross-reactive with the major serum idiotypes (reviewed in Ref. 8). Although the VH gene products expressed on T and B cells may overlap, (9,10) the fine specificity of the repertoire may not be identical(11,12) The constant-region markers (isotypes) on B cells have never been found to be expressed on the surface of T cells.(13)


Linkage Group Fetal Liver Suppressor Cell Antigen Receptor Antigen Binding 


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Frances L. Owen
    • 1
  1. 1.Department of Pathology and Cancer Research CenterTufts University School of MedicineBostonUSA

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