Role of Idiotypes in the (4-Hydroxy-3-Nitrophenyl) Acetyl (NP)-Specific Suppressor T-Cell Pathway

  • David H. Sherr
  • Michael J. Onyon
  • Martin E. Dorf


It has recently become evident that modulation of the immune response can be effected by regulatory elements which recognize unique idiotypic determinants associated with the binding site of antibody molecules. For example, injection of mice with antigen(1) or idiotypic antibodies(2) results in the production of autoantibody specific for predominant idiotypic determinants. Injection of anti-idiotypic antibodies may similarly result in the appearance of idiotypic antibody.(3) These data support the hypothesis first proposed by Jerne predicting the participation of complementary idiotypic-anti-idiotypic antibodies in the regulation of the immune response.(4)


Spleen Cell Effector Phase Contact Sensitivity Responder Cell Preferential Suppression 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • David H. Sherr
    • 1
  • Michael J. Onyon
    • 1
  • Martin E. Dorf
    • 1
  1. 1.Department of PathologyHarvard Medical SchoolBostonUSA

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