Suppressor T-Cell Hybridoma with a Receptor Recognizing KLH-Specific Suppressor Factor

  • Masaru Taniguchi
  • Izumi Takei
  • Takayuki Sumida
  • Masamoto Kanno
  • Masatoshi Tagawa
  • Toshihiro Ito


Immune responses are known to be regulated by complicated interactions of T-cell subsets that play different functional roles.(1–6) In our previous studies of the cellular mechanisms in the suppression of antibody response, at least three functionally distinct subsets of suppressor T cells, i.e., suppressor T cells producing antigen-specific factor (TsF), suppressor T cells with acceptor site for TsF (acceptor T cell), and effector-suppressor T cells, were found to be involved in the regulatory T-cell interactions.(1) The initial step of suppressor T cell interaction is a process of activation of acceptor T cells by an antigen-specific TsF. The effector-suppressor T cells are then generated under the influence of activated acceptor T cells. Therefore, antigen-specific TsF mediates the regulatory T-cell interaction in which no direct cell contact is necessary. Moreover, antigen-specific TsF seems not to be an effector-suppressor molecule but rather a molecule whose function is to activate other subsets of suppressor T cells. In this sense, the antigen-specific TsF appears to work as a device to recognize antigens and also to communicate with other T cells.


Light Chain Heavy Chain Suppressor Activity Translation Product Suppressor Factor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Masaru Taniguchi
    • 1
  • Izumi Takei
    • 1
  • Takayuki Sumida
    • 1
  • Masamoto Kanno
    • 1
  • Masatoshi Tagawa
    • 1
  • Toshihiro Ito
    • 1
  1. 1.Department of Immunology, School of MedicineChiba UniversityChiba, 280Japan

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