Idiotype Regulation in the Antibody Response to Phosphocholine

Antigen Selection of B-Lymphocyte Subsets with Differential Idiotype Expression?
  • D. E. Mosier
  • Ann J. Feeney


The antibody response to many natural or experimental antigens is often dominated by a single family of immunoglobulin molecules directly encoded by or derived from a single germ-line variable-region gene.(1–3) This is the case even though a number of alternative antibodies with apparent specificity for the same antigen can be produced(4–7) The essential question we wish to address concerns the mechanism by which one gene product is selected from many for expression in the antibody response. If we assume that all V genes have an equal opportunity for expression at the pre-B-cell level, then a given B-cell clone must be expanded to become dominant either by antigen selection or by a regulatory system that can distinguish one V region from another, i.e., an idiotypic network.(8) While both types of regulatory mechanisms could operate simultaneously, we wish to present in this chapter some recent observations that lead us to emphasize the importance of antigen selection acting on distinct emerging B-cell subpopulations in explaining the idiotype composition of the murine antiphosphocholine (anti-PC) response.


Antibody Response Helper Cell Tolerance Induction Idiotypic Network Heavy Chain Variable Region 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • D. E. Mosier
    • 1
  • Ann J. Feeney
    • 1
  1. 1.Institute for cancer ResearchPhiladelphiaUSA

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