Autologous Idiotope-Specific T Cells in Regulation of Antibody Response

  • Jan Cerny


The existence of autologous anti-idiotypic (anti-Id) lymphocytes—both B and T cells—has been convincingly demonstrated using various experimental manipulations described elsewhere in this volume. When they are activated with an appropriate probe (e.g., Id-bearing molecules or cells), the anti-Id cells and their products display a strong regulatory effect on the immune response of lymphocytes bearing the corresponding Id. Whether the anti-Id response is an autochthonous process that occurs within the system without any manipulation is less certain. This assumption, which is the cornerstone of the network hypothesis of immune self-regulation,(1) has been questioned by several investigators.(2,3) Does lymphocyte stimulation with antigen always induce a complementary anti-Id reaction? How important is this autochthonous anti-Id response for regulation of the first response? What is the internal mechanism of activation of anti-Id clones? In this chapter we will try to strenghten the case for anti-Id self-regulation by providing experimental data in answer to the aforementioned questions.


Nude Mouse Spleen Cell Splenic Lymphocyte Myeloma Protein Complementary Clone 


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Jan Cerny
    • 1
  1. 1.Department of MicrobiologyUniversity of Texas Medical BranchGalvestonUSA

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