Helper T-Lymphocyte Influences on Idiotype-Bearing B Cells

  • Kim Bottomly
  • Eileen Dunn


Lyt-1+ T-B-cell interactions can be delineated best by understanding the characteristics of the individual T and B lymphocytes, including their specificity, cell surface markers, function, and requirements for activation. Previous studies have placed T cells in subsets based on functional differences and perhaps more convincingly on the expression of unique surface markers correlating with the specialized function of the subset. More recently, Lyt-1+ T cells have been further delineated by their dependence on the presence of either major histocompatibility complex (MHC)-encoded determinants(1–11) or immunoglobulin (Ig)-encoded determinants.(12–34) This recognition requirement has been demonstrated both for the activation of the T-cell subset and for its subsequent interaction with the target B cell.


Major Histocompatibility Complex Antibody Response Helper Cell Myeloma Protein Carrier Antigen 


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Kim Bottomly
  • Eileen Dunn
    • 1
  1. 1.Department of PathologyYale University Medical SchoolNew HavenUSA

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