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The Role of Idiotype and of Immunoglobulin in T-Cell Differentiation and Function

  • Charles A. JanewayJr.

Abstract

A great deal of attention has appropriately been directed to the role of genes encoded in the major histocompatibility complex (MHC) in T-cell development, antigen recognition by T cells, and cell interactions involving T cells. However, it seems likely that not all T cells are under the influence of MHC-linked genes. Some T cells appear to be involved in recognition and regulation of immunoglobulin (Ig) gene products, or products of loci linked to the Igh genes. I have previously reviewed the characteristics of some of these cells in several different articles,(1–3) and I will not repeat those descriptions here. Rather, I would like to focus on the role of Ig and of idiotypic Ig in particular (Id) in T-cell maturation and function.

Keywords

Major Histocompatibility Complex Antibody Response Bacterial Antigen Normal Mouse Serum Myeloma Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Charles A. JanewayJr.
    • 1
  1. 1.Department of Pathology, Immunology Division, and The Howard Hughes Medical InstituteYale University School of MedicineNew HavenUSA

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