The Role of Idiotype and of Immunoglobulin in T-Cell Differentiation and Function

  • Charles A. JanewayJr.


A great deal of attention has appropriately been directed to the role of genes encoded in the major histocompatibility complex (MHC) in T-cell development, antigen recognition by T cells, and cell interactions involving T cells. However, it seems likely that not all T cells are under the influence of MHC-linked genes. Some T cells appear to be involved in recognition and regulation of immunoglobulin (Ig) gene products, or products of loci linked to the Igh genes. I have previously reviewed the characteristics of some of these cells in several different articles,(1–3) and I will not repeat those descriptions here. Rather, I would like to focus on the role of Ig and of idiotypic Ig in particular (Id) in T-cell maturation and function.


Major Histocompatibility Complex Antibody Response Bacterial Antigen Normal Mouse Serum Myeloma Protein 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Charles A. JanewayJr.
    • 1
  1. 1.Department of Pathology, Immunology Division, and The Howard Hughes Medical InstituteYale University School of MedicineNew HavenUSA

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