Idiotype and Anti-Idiotype Regulation of Antipolyfructosan Response

Role of Regulatory Idiotopes
  • Constantin A. Bona


The key element of the network theory of the immune system proposed by Jerne(1) is the potential importance of receptor-specific regulation of the immune response.


Immune Network Monoclonal Protein Internal Image Idiotypic Network Myeloma Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Jerne, N. K., 1974, Towards a network theory of the immune response, Ann. Immunol. (Inst. Pasteur) 125C:373–389.Google Scholar
  2. 2.
    Winkler, M., Franssen, J. D., Collignon, C., Leo, O., Mariaime, B., van de Walle, P., de Groote, D., and Urbain, J., 1979, Idiotypic regulation of the immune system: Common idiotypic specificities between idiotopes and antibodies raised against anti-idiotypic antibodies in rabbits, J. Exp. Med. 150:184–195.PubMedCrossRefGoogle Scholar
  3. 3.
    Bona, C. A., Heber-Katz, E., and Paul, W. E., 1981, Idiotype anti-idiotype regulation. I. Immunization with a levan binding myeloma protein leads to the appearance of auto-anti(anti-idiotypes) antibodies and to the activation of silent clones, J. Exp. Med. 153:951–967.PubMedCrossRefGoogle Scholar
  4. 4.
    Rodkey, L. S., 1980, Autoregulation of immune response via idiotypic network interactions, Microbiol. Res. 49:631–659.Google Scholar
  5. 5.
    Paul, W. E., and Bona, C., 1982, Regulatory idiotopes and immune networks: A hypothesis, Immunol. Today 3:230–234.CrossRefGoogle Scholar
  6. 6.
    Rubinstein, L. J., Yeh, M., and Bona, C. A., 1982, Idiotype-anti-idiotype network. II. Activation of silent clones by treatment at birth with idiotypes is associated with the expansion of idiotype-specific helper T cells, J. Exp. Med. 156:506–521.PubMedCrossRefGoogle Scholar
  7. 7.
    Olio, R., Auffrey, C., Sikorov, J. L., and Rougeon, F., 1981, Mouse heavy chain variable region: Nucleotide sequences of a germ line Vh gene segment, Nucleic Acids Res. 9:4098–4109.Google Scholar
  8. 8.
    Goldberg, B., Paul, W. E., and Bona, C., 1983, Idiotype-anti-idiotype regulation. IV. Characterization of regulatory idiotopes on ß2–6 fructosan binding monoclonal antibodies and monoclonal proteins with different antigen specificities, J. Exp. Med. 158:515–528.PubMedCrossRefGoogle Scholar
  9. 9.
    Sachs, D. L., Kelsoe, G. H., and Sachs, D. H., 1983, Induction of immune response with anti-idiotypic antibodies: Implications for the induction of protective immunity, Springer Semin. Immunopathol. 6:79–97.PubMedCrossRefGoogle Scholar
  10. 10.
    Legrain, P., and Buttin, G., 1983, The level of expression and the molecular distribution of ABPC48 idiotopes in levan or anti-idiotope primed BALB/c mice, in: Immune Networks (C. Bona and H. Kohler, eds.), Ann. NY Acad. Sci. 418:290–296Google Scholar
  11. 11.
    Bona, C., 1984, Regulatory idiotopes, in: Idiotype Manipulation in Biological Systems (H. Kohler, P. A. Cazenave, and J. Urbain, eds.), Academic Press, New York, pp. 29–41.Google Scholar
  12. 12.
    Auffrey, C., Sikorov, J. L., Olio, R., and Rougeon, F., 1981, Correlation between D region structure and antigen-binding specificity: Evidence from the comparison of closely related immunolobulin VH sequence, Ann. Immunol. (Inst. Pasteur). 132D:77–88.Google Scholar
  13. 13.
    Seising, E., and Storb, W., 1981, Somatic mutation of immunoglobulin light-chain variable region genes, Cell 25:45–58.Google Scholar
  14. 14.
    Kabat, E. A., Wu, T. T., and Bilofsky, H., 1979, Sequence of Immunoglobulin Chains, U.S. Department of Health, Education and Welfare.Google Scholar
  15. 15.
    Bona, C., 1981, Idiotype and Lymphocytes, Academic Press, New York.Google Scholar
  16. 16.
    Bona, C., Lieberman, R., Chien, C. C., Mond, J., House, S., Green, I., and Paul, W. E. 1978, Immune response to levan. I. Kinetics and ontogeny of anti-levan and anti-inulin antibody response and of expression of cross-reactive idiotype, f. Immunol. 120:1436–1442.Google Scholar
  17. 17.
    Hiernaux, J., Bona, C., and Baker, T. J., 1981, Neonatal treatment with low doses of anti-idiotypic antibodies leads to the expression of a silent clone, f. Exp. Med. 153:1006–1008.Google Scholar
  18. 18.
    Rubinstein, L. J., and Bona, C., 1983, Idiotype-anti-idiotype network. III. Genetic control of activation of A48Id silent clones subsequent to manipulation of the immune network, in: Immune Networks (C. Bona and H. Kohler, eds.), Ann. N Y Acad. Sci. 418:97–109.Google Scholar
  19. 19.
    Rubinstein, L. J., Goldberg, B., Hierneux, J., Stein, K. G., and Bona, C., 1983, Idiotype-anti-idiotype regulation. V. The requirement for immunization with antigen or monoclonal anti-idiotypic antibodies for the activation of β2→6 and β2→l polyfructosan reactive clones in BALB/c mice treated at birth with minute amounts of anti-A48 idiotype antibodies, J. Exp. Med. 158:1129–1144.PubMedCrossRefGoogle Scholar
  20. 20.
    Bona, C., and Pernis, B., 1983, Immune networks, in: Fundamental Immunology (W. E. Paul, ed.), Raven Press, New York, pp. 577–592.Google Scholar
  21. 21.
    Kelsoe, G., Reth, M., and Rajewsky, K., 1981, Control of idiotype expression by monoclonal anti-idiotype and idiotype-bearing antibody, Eur. J. Immunol. 11:418–423.PubMedCrossRefGoogle Scholar
  22. 22.
    Heyman, B., Andrighetto, G., and Wigzell, H., 1982, Antigen-dependent IgM mediated enhancement of the sheep erythrocytes response in mice, J. Exp. Med. 155:994–1009.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Constantin A. Bona
    • 1
  1. 1.Department of MicrobiologyMount Sinai School of MedicineNew YorkUSA

Personalised recommendations