Murine Plasmacytoma MOPC315 as a Tool for the Analysis of Network Regulation

M315 Idiotopes Are Inducers and Targets of Immunoregulatory Signals
  • Richard G. Lynch
  • Gary L. Milburn


A great deal of what is presently known about antibody molecules, their idiotypes, and their genes has come from studies of neoplastic antibody-producing cells. Typically, such studies have used an approach in which a myeloma cell provided the investigator with large quantities of a single, specific, readily purified macromolecule, e.g., an antibody, an RNA, or an immunoglobulin gene. This strategy has been successfully used to establish the primary, secondary, and tertiary structures of antibody molecules(1–3) to develop the molecular probes that specifically detect immunoglobulin genes and RNAs,(4) and to identify the chromosomal location(5) and the molecular organization and nucleotide sequences of immunoglobulin genes.(6,7)


Light Chain Myeloma Cell Suppressor Cell Immunoglobulin Gene Idiotypic Network 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Richard G. Lynch
    • 1
  • Gary L. Milburn
    • 1
  1. 1.Department of PathologyUniversity of Iowa College of MedicineIowa CityUSA

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