Expression of Anti-MHC Idiotypes in Immune Responses

  • Suzanne L. Epstein
  • Jeffrey A. Bluestone
  • David H. Sachs


Major histocompatibility complex (MHC) antigens are the targets of immune attack recognized during graft rejection and graft-versus-host (GVH) reactions. Therefore, a knowledge of the nature of anti-MHC receptors may allow specific intervention to alter the course of these clinically important reactions. The MHC antigens also function as stimulators and targets of allogeneic reactions such as mixed lymphocyte reactions and cell-mediated lympholysis, and as restriction elements for immune responses to foreign antigens. Thus, the generation and regulation of a wide variety of immune responses is governed by the recognition of this set of antigens. Both of these considerations have given impetus to the study of lymphocyte receptors for histocompatibility antigens.


Major Histocompatibility Complex Keyhole Limpet Hemocyanin Mixed Lymphocyte Reaction Major Histocompatibility Complex Antigen Antibody Idiotype 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Suzanne L. Epstein
    • 1
  • Jeffrey A. Bluestone
    • 1
  • David H. Sachs
    • 1
  1. 1.Transplantation Biology Section, Immunology BranchNational Cancer InstituteBethesdaUSA

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