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Genetic and Environmental Control of B-Cell Idiotype Expression

  • Dorith Zharhary
  • Richard L. Riley
  • Barbara G. Froscher
  • Norman R. Klinman

Abstract

Since the earliest demonstrations that the immune system of an individual has the capacity to recognize its own antibody variable regions, the potential role of such anti-idiotypic recognition in the regulation of immune responses has gained considerable attention(1,2)Studies which have utilized the passive transfer of anti-idiotypic antibodies have defined several levels at which anti-idiotypic recognition can affect immune responsiveness.(3–12) These include the inhibition of antigenic stimulation of idiotype-positive cells,(3–5)the direct stimulation of idiotype-positive cells,(5–8) the elimination of B cells of the appropriate idiotype from within the mature B-cell repertoire(9,10) and the enhancement of the expression of idiotype-positive cells(11,12) Finally, the physiological relevance of idiotypic recognition has been demonstrated by the finding that such recognition becomes a predominant feature of the immune system subsequent to immunization.(13)

Keywords

Spleen Cell Aged Mouse Antigenic Stimulation Environmental Antigen Antiidiotypic Antibody 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Dorith Zharhary
    • 1
  • Richard L. Riley
    • 1
  • Barbara G. Froscher
    • 1
  • Norman R. Klinman
    • 1
  1. 1.Department of ImmunologyScripps Clinic and Research FoundationLa JollaUSA

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