Cross-Reacting Idiotypes in the Human System
One of the most striking phenomena regarding anti-idiotypic antisera and monoclonal antibodies is the remarkable cross-reactions observed. This is certainly true in the human system. These cross-reactions extend well beyond simple immunoglobulin variable regions but also involve ordinary cell receptors as well as the T-cell receptors for specific antigens. In fact, the latter cross-reaction between immunoglobulins and T-cells receptors has been misleading and led to the broad impression that similar Vgenes are involved. Current evidence indicates that this is not the case.(1,2) Much of the work in the human system has been carried out on autoantibodies, particularly those that appear in monoclonal form. Idiotypic cross-reactions are striking in these autoantibodies, and this may be a special characteristic of these antibodies. In this discussion a number of these autoantibody systems will be reviewed with special emphasis on the chemical basis for certain of the cross-reacting idiotypes (CRI). In addition, recent work on T-cell-specific idiotypes and CRIs will be discussed.
KeywordsLight Chain Rheumatoid Factor Rabbit Antiserum Cold Agglutinin Thyroglobulin Antibody
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- 1.Kraig, E., Kronenberg, M., Kapp, J. A., Pierce, C. W., Abruzzini, A. F., Sorensen, C. M., Salemson, L. E., Schwartz, R. H., and Hood, L. E., 1983, T and B cells that recognize the same antigen do not contain detectable heavy-chain variable gene transcripts, J. Exp. Med. 158 (1):210–227.PubMedCrossRefGoogle Scholar
- 4.Kabat, E. A., and Mayer, M. M., 1961, Experimental Immunochemistry Thomas, Springfield, III.Google Scholar
- 12.Andrews, D. W., and Capra, J. D., 1981, Complete amino acid sequence of variable domains from two monoclonal human anti-gamma globulins of the Wa cross-idiotypic group: Suggestion that the J segments are involved in the structural correlate of the idiotype, Proc. Natl. Acad. Sci. USA 78:3799–3803.PubMedCrossRefGoogle Scholar
- 15.Posnett, D. N., Pernis, B., and Kunkel, H. G., 1984, Dissection of the anti-7 globulin idiotype system with monoclonal antibodies, in preparation.Google Scholar
- 17.Westen-Schnurr, I. (ed.), 1982, Idiotypes, Antigens on the Inside, Roche Press, Basel.Google Scholar