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Antibody Diversity in the Response to Streptococcal Group A Carbohydrate

  • Chapter
The Biology of Idiotypes

Abstract

In the past several years, a number of laboratories have used the murine antibody response to streptococcal group A carbohydrate (GAC) as a model system in which to study the development and regulation of humoral immunity. This system displays a number of features which are common to other antigen-antibody systems as well as unique features which make it particularly suitable to the study of antibody diversity. The scope of this chapter is to review the major characteristics of this antibody response and to discuss in more detail recent experiments from our laboratory which have exploited the anti-GAC response to ask questions concerning the rules which govern the pairing of heavy- and light-chain variable regions in the generation of antibody diversity. As with most other antibody systems which have been examined in detail, it has become increasingly apparent that the antibody response to GAC is assembled from a restricted set of heavy- and light-chain variable regions and constant regions. These observations have raised questions about the extent to which combinatorial diversity functions within the immune system and suggest the possibility that coordinated regulation results in the expression of VL, VH, and CH gene products in restricted sets, irrespective of the constraints imposed by an antigen-specific system.

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Author information

Author notes

  1. R. Jerrold Fulton

    Present address: Department of Microbiology, University of Texas Health Science Center, 75235, Dallas, Texas, USA

Authors and Affiliations

  1. Departments of Microbiology and Immunology and of Pathology, Washington University School of Medicine, 63110, St. Louis, Missouri, USA

    R. Jerrold Fulton, Moon H. Nahm, Neil S. Greenspan & Joseph M. Davie

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  1. R. Jerrold Fulton
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  2. Moon H. Nahm
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  3. Neil S. Greenspan
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  4. Joseph M. Davie
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Editor information

Editors and Affiliations

  1. Department of Pathology, Harvard Medical School, 02115, Boston, Massachusetts, USA

    Mark I. Greene

  2. Rosenstiel Research Center, Brandeis University, Waltham, Massachusetts, USA

    Alfred Nisonoff

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© 1984 Plenum Press, New York

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Fulton, R.J., Nahm, M.H., Greenspan, N.S., Davie, J.M. (1984). Antibody Diversity in the Response to Streptococcal Group A Carbohydrate. In: Greene, M.I., Nisonoff, A. (eds) The Biology of Idiotypes. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4739-2_12

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  • DOI: https://doi.org/10.1007/978-1-4684-4739-2_12

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4741-5

  • Online ISBN: 978-1-4684-4739-2

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