Antibody Diversity in the Response to Streptococcal Group A Carbohydrate
In the past several years, a number of laboratories have used the murine antibody response to streptococcal group A carbohydrate (GAC) as a model system in which to study the development and regulation of humoral immunity. This system displays a number of features which are common to other antigen-antibody systems as well as unique features which make it particularly suitable to the study of antibody diversity. The scope of this chapter is to review the major characteristics of this antibody response and to discuss in more detail recent experiments from our laboratory which have exploited the anti-GAC response to ask questions concerning the rules which govern the pairing of heavy- and light-chain variable regions in the generation of antibody diversity. As with most other antibody systems which have been examined in detail, it has become increasingly apparent that the antibody response to GAC is assembled from a restricted set of heavy- and light-chain variable regions and constant regions. These observations have raised questions about the extent to which combinatorial diversity functions within the immune system and suggest the possibility that coordinated regulation results in the expression of VL, VH, and CH gene products in restricted sets, irrespective of the constraints imposed by an antigen-specific system.
KeywordsLight Chain Antibody Response Immunoglobulin Heavy Chain Antibody Diversity Immunoglobulin Variable Region
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