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Rhinoviruses

  • Jack M. GwaltneyJr.

Abstract

Rhinoviruses are the most important common cold viruses to be discovered. The name rhinovirus reflects the prominent nasal involvement seen in infections with these viruses. The large rhinovirus genus, which is a member of the picornavirus family, contains over 100 different antigenic types. The discovery of the rhinoviruses led to the realization that the common cold is an enormously complex syndrome. The number of antigenically distinct rhinoviruses is so large that man can be infected with a different rhinovirus each year and still not experience all the known types in a lifetime. Awareness of the complexity of the rhinovirus problem has discouraged work on the development of common-cold vaccines and stimulated interest in alternative approaches to control, such as chemoprophylaxis and environmental measures. Although rhinoviruses are the best studied of the common-cold viruses, major gaps still remain in knowledge of their epidemiological behavior. The fundamental question of the number of antigenic types in existence is unanswered, as is the related question of the possible occurrence of antigenic drift of serotypes.

Keywords

Common Cold Respiratory Virus Nasal Secretion WI38 Cell Antigenic Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Suggested Reading

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Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Jack M. GwaltneyJr.
    • 1
  1. 1.Department of Internal MedicineUniversity of Virginia School of MedicineCharlottesvilleUSA

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