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Epstein—Barr Virus

  • Alfred S. Evans
  • James C. Niederman

Abstract

Epstein—Barr virus (EBV), a member of the herpes group of viruses, is the cause of heterophile-positive infectious mononucleosis, of most heterophile-negative cases, and of occasional cases of tonsillitis and pharyngitis in childhood. Rarely, it may involve the liver or central nervous system as primary manifestations. This virus is strongly implicated as having a causal relationship to African Burkitt lymphoma and to nasopharyngeal cancer. High antibody titers are also present in 30–40% of cases of Hodgkin’s disease, in some patients with sarcoidosis, and in systemic lupus erythematosus.

Keywords

Burkitt Lymphoma Infectious Mononucleosis Early Antigen Military Academy Clinical Infectious Mononucleosis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Armstrong, D., Henle, G., and Henle, W., Complement-fixation tests with cell lines derived from Burkitt’s lymphoma and acute leukemias, J. Bacteriol. 91: 1257–1262 (1966).PubMedGoogle Scholar
  2. 1a.
    Armstrong, J. A., Evans, A. S., Rao, N., and Ho, M., Viral infections in renal transplant recipients, Infect. Immun. 14: 970–975 (1976).PubMedGoogle Scholar
  3. 2.
    Bailey, G. H., and Raffel, S., Hemolytic antibodies for sheep and ox erythrocytes in infectious mononucleosis, J. Clin. Invest. 14: 228–244 (1935).PubMedGoogle Scholar
  4. 3.
    Banatvala, J. E., Best, J. M., and Waller, D. K., Epstein-Barr virus-specific IgM in infectious mononucleosis, Burkitt lymphoma, and nasopharyngeal carcinoma, Lancet 1: 1205–1208 (1972).PubMedGoogle Scholar
  5. 4.
    Bang, J., Forsoeg paa at overfoere mononucleosis infectiosa til mennesket, Ugeshkr. Laeg. 105: 499–504 (1943).Google Scholar
  6. 5.
    Bar, R. S., Delor, J., Clausen, K. P., Hurtubise, P., Henle, W., and Hewetson, J. F., Fatal infectious mononucleosis in a family, N. Engl. J. Med. 290: 363–367 (1974).PubMedGoogle Scholar
  7. 6.
    Barondess, J. A., and Erle, H., Serum alkaline phosphatase activity in hepatitis of infectious mononucleosis, Am. J. Med. 29: 43–54 (1960).PubMedGoogle Scholar
  8. 7.
    Bauscher, J. C., and Smith, R. T., Studies of Epstein-Barr virus-host-relationship: Autochthonous and allogeneic lymphocyte stimulation by lymphoblast cell lines in mixed cell culture, Clin. Immunol. Immunopathol. 1: 270–281 (1973).Google Scholar
  9. 8.
    Bender, C. E., Interpretation of hematologic and serologic findings in the diagnosis of infectious mononucleosis, Ann. Intern. Med. 49: 852–865 (1958).PubMedGoogle Scholar
  10. 9.
    Bender, E. C., Recurrent mononucleosis, J. Am. Med. Assoc. 182: 954–956 (1962).Google Scholar
  11. 10.
    Bentzon, J. W., The effect of certain infectious diseases on tuberculin allergy, Tubercle 34: 34–41 (1953).PubMedGoogle Scholar
  12. 10a.
    Biggar, R. J., Henle, W., Fleischer, G., Böcker, J., Lennette, E. T., and Henle, G., Primary Epstein-Barr virus infections in African infants. I. Decline of maternal antibodies and time of infection, Int. J. Cancer 22: 239–243 (1978).PubMedGoogle Scholar
  13. 10b.
    Biggar, R. J., Henle, G., Böcker, J., Lennette, E. T., Fleischer, G., and Henle, W., Primary Epstein-Barr virus infections in African infants. II. Clinical and serological observations during seroconversion, Int. J. Cancer 22: 244–250 (1978).PubMedGoogle Scholar
  14. 11.
    Black, F. L., Hierholzer, W. J., Pinheiro, DEP., Evans, A. S., Woodall, J. P., Opton, E. M., Em-Mons, J. E., West, B. S., Edsall, G., Downs, W. G., and Wallace, G. D., Evidence for persistence of infectious agents in isolated human populations, Am. J. Epidemiol. 100: 230–250 (1974).PubMedGoogle Scholar
  15. 12.
    Bloedorn, W. A., and Houghton, J. E., The occurrence of abnormal leucocytes in the blood in acute infections, Arch. Intern. Med. 27: 315–325 (1921).Google Scholar
  16. 12a.
    Boon, W. H., Mui, C. L. Y., and Too, M., Infectious mononucleosis in Singapore, J. Singapore Pediatr. Soc. 19: 153–161 (1977).Google Scholar
  17. 13.
    Brown, J. W., Clifford, J. E., Sims, J. L., and White, E., Liver function during infectious mononucleosis, Am. J. Med. 6: 321–328 (1949).PubMedGoogle Scholar
  18. 14.
    Cabot, R. C., The lymphocytosis of infection, Am. J. Med. Sci. 145: 335–339 (1913).Google Scholar
  19. 15.
    Carlson, G. W., Brooks, E. H., and Marshall, V. F., Acute glandular fever: Recent epidemic, report of cases, Wis. Med. J. 25: 176–178 (1926).Google Scholar
  20. 16.
    Carter, R. L., and Penman, H. G., The early history of infectious mononucleosis and its relation to “glandular fever,” in: Infectious Mononucleosis (R. L. CARTER and H. G. PENMAN, eds.), Blackwell, Oxford, 1969.Google Scholar
  21. 17.
    Carvalho, R. P. S., Evans, A. S., Frost, P., Dalldorf, G., Camargo, M. E., and Jarma, M., EBV infection in Brazil. I. Occurrence in normal persons, in lymphomas and in leukemias, Int. J. Cancer 11:191–201 (1973).Google Scholar
  22. 18.
    Center For Disease Control, Infectious Mononucleosis Surveillance, November 1972.Google Scholar
  23. 19.
    Chang, R. S., and Golden, H. D., Transformation of human leucocytes by throat washings from infectious mononucleosis patients, Nature (London) 234: 359–360 (1971).Google Scholar
  24. 20.
    Chang, R. S., Lewis, J. P., and Abildgaard, C. F., Excretors of leucocyte-transforming agents among a human population, N. Engl. J. Med. 289: 1328–1329 (1973).Google Scholar
  25. 21.
    Christine, B. W., Infectious mononucleosis, Conn. Health Bull. 82: 115–119 (1968).Google Scholar
  26. 21a.
    Connecticut State Health Department, Personal communication.Google Scholar
  27. 21b.
    Corey, L., Stamm, W. E., Feorino, P. M., Bryan, J. A., Weseley, S., Gregg, M. B., and Solangi, K., HB, AG-negative hepatitis in a hemodialysis unit: Relation to Epstein-Barr virus, N. Engl. J. Med. 293: 1273–1278 (1975).PubMedGoogle Scholar
  28. 22.
    Cross, J. G., Conditions simulating an acute leukemia (acute benign leukemia), Minn. Med. 5: 579–581 (1922).Google Scholar
  29. 23.
    Davidsohn, I., and Walker, P. H., The nature of the heterophilic antibodies in infectious mononucleosis, Am. J. Clin. Pathol. 5: 455–465 (1935).Google Scholar
  30. 24.
    Davidsohn, I., Heterophile antibodies in serum sickness, J. Immunol. 16: 259–273 (1929).Google Scholar
  31. 25.
    Davidsohn, R. J. L., A survey of infectious mononucleosis in the North-East Regional Hospital Board area of Scotland, 1960–9, J. Hyg. 68: 393–400 (1970).Google Scholar
  32. 26.
    Diehl, V., Henle, G., Henle, W., and Kohn, G., Demonstration of a herpes group virus in cultures of peripheral leukocytes from patients with infectious mononucleosis, J. Virol. 2: 663–669 (1968).Google Scholar
  33. 27.
    Dingle, J. H., Badger, G. F., and Jordan, W. S., Jr., Illness in the Home: A Study of 25,000 Illnesses in a Group of Cleveland Families, The Press of Western Reserve, Cleveland, 1964.Google Scholar
  34. 28.
    Downey, H., and Mckinlay, C. A., Acute lymphadenosis compared with acute lymphatic leukemia, Arch. Intern. Med. 32: 82–112 (1923).Google Scholar
  35. 29.
    Edwards, J. M. B., and Mcswiggan, D. A., Studies on the diagnostic value of an immunofluorescence test for EB virus specific IgM, Clin. Pathol. 27: 647–651 (1974).Google Scholar
  36. 29a.
    Edwards, J. M. B., Vandervelde, E. M., Cohen, B. J., and Mcswiggan, D. A., Laboratory diagnosis of EB virus infection in some cases presenting as hepatitis, J. Clin. Pathol. 31: 179–182 (1978).PubMedGoogle Scholar
  37. 30.
    Ellenbogen, C., and Reinarz, J. A., The Epstein-Barr virus and its relationship to infectious mononucleosis in air force recruits, Mil. Med. 140: 371–373 (1974).Google Scholar
  38. 31.
    Enberg, R. N., Eberle, B. J., and Williams, R. C., Peripheral blood T and B cells in infectious mononucleosis, J. Infect. Dis. 130: 104–111 (1974).PubMedGoogle Scholar
  39. 32.
    Epstein, M. A., and Achong, B. G., Various forms of Epstein-Barr virus infection in man: Established facts and a general concept, Lancet 2: 836–839 (1973).PubMedGoogle Scholar
  40. 32a.
    Epstein, M. A., and Achong, B. G., Pathogenesis of infectious mononucleosis, Lancet 2: 1270–1278 (1977).PubMedGoogle Scholar
  41. 33.
    Epstein, M. A., Achong, B. G., and Barr, Y. M., Chapter 10 • Epstein-Barr Virus Virus particles in cultured lymphoblasts from Burkitt’s lymphoma, Lancet 1: 702–703 (1964).PubMedGoogle Scholar
  42. 34.
    Evans, A. S., Experimental attempts to transmit infectious mononucleosis to man, Yale J. Biol. Med. 20: 19–26 (1947).PubMedGoogle Scholar
  43. 35.
    Evans, A. S., Liver function tests in infectious mononucleosis, J. Clin. Invest. 27: 106–110 (1948).Google Scholar
  44. 36.
    Evans, A. S., Further experimental attempts to transmit infectious mononucleosis to man, J. Clin. Invest. 29: 508–512 (1950).PubMedGoogle Scholar
  45. 37.
    Evans, A. S., Infectious mononucleosis in University of Wisconsin students: Report of a five-year investigation, Am. J. Hyg. 71: 342–362 (1960).PubMedGoogle Scholar
  46. 38.
    Evans, A. S., Infectious mononucleosis: Observations from a public health laboratory, Yale J. Biol. Med. 34:261–276 (1961/1962).PubMedGoogle Scholar
  47. 39.
    Evans, A. S., Complications of infectious mononucleosis: Recognition and management, Hosp. Med. 3:24–25, 28–33 (1967).Google Scholar
  48. 40.
    Evans, A. S., Infectious mononucleosis: Recent developments, Gen. Pract. 60: 127–134 (1969).Google Scholar
  49. 41.
    Evans, A. S. Infectious mononucleosis in the armed forces, Mil. Med. 135: 300–304 (1970).PubMedGoogle Scholar
  50. 42.
    Evans, A. S., New discoveries in infectious mononucleosis, Mod. Med. 1: 18–24 (1974).Google Scholar
  51. 43.
    Evans, A. S., The history of infectious mononucleosis, Am. J. Med. Sci. 267: 189–195 (1974).PubMedGoogle Scholar
  52. 44.
    Evans, A. S., Commentary-EB virus, infectious mononucleosis and cancer: The closing of the web, Yale J. Biol. Med. 47: 113–122 (1974).PubMedGoogle Scholar
  53. 44a.
    Evans, A. S., Infectious mononucleosis and related syndromes, Am. J. Med. Sci. 276: 325–339 (1978).Google Scholar
  54. 45.
    Evans, A. S., and Robinton, E. D., An epidemiologic study of infectious mononucleosis in a New England college, N. Engl. J. Med. 242: 492–496 (1950).Google Scholar
  55. 46.
    Evans, A. S., and Paul, J. R., Infectious mononucleosis, in: Preventive Medicine in World War II, Vol. V: Communicable Diseases (J. B. Coates, Jr., ed.), Office of the Surgeon General, Department of the Army, Washington, D.C., 1960.Google Scholar
  56. 47.
    Evans, A. S., and Campos, L. E., Acute respiratory diseases in students at the University of the Philippines, Bull. WHO 45: 103–112 (1971).PubMedGoogle Scholar
  57. 48.
    Evans, A. S., Carvalho, R. P. S., and Grossman, L., EBV infections in Brazil. III. Infectious mononucleosis, Unpublished (1974).Google Scholar
  58. 49.
    Evans, A. S., Evans, B. K., and Sturtz, V., Standards for hepatic and hematologic tests in monkeys: Observations during experiments with hepatitis and mononucleosis, Proc. Soc. Exp. Biol. Med. 82: 437–440 (1953).PubMedGoogle Scholar
  59. 50.
    Evans, A. S., Niederman, J. C., and Mccollum, R. W., Seroepidemiological studies of infectious mononucleosis with EB virus, N. Engl. J. Med. 279: 1121–1127 (1968).PubMedGoogle Scholar
  60. 51.
    Evans, A. S., Jensen, R., Niederman, J. C., and Wallace, D. K., Studies of EBV antibody in Fort Jackson military recruits, Unpublished data (1974).Google Scholar
  61. 52.
    Evans, A. S., Niederman, J. C., Cenabre, L. C., West, B., and Richards, V. A., A prospective evaluation of heterophile and Epstein-Barr virus-specific IgM antibody tests in clinical and subclinical infectious mononucleosis: Specificity and sensitivity of the tests and persistence of antibody, J. Infect. Dis. 132: 546–554 (1975).PubMedGoogle Scholar
  62. 53.
    Filatov, N. F., Semiotik and Diagnotik de Kinderkrankheiten, Verlag von Ferdinand Enke, Stuttgart, 1892.Google Scholar
  63. 54.
    Filatov, N. F., Lektuse ob ostrikh infektsion nikh lolieznyak (Lectures on acute infectious diseases of children), Moscow, U Deitel, 1885; cited by Wising, P. J., Acta Med. Scand. Suppl. 133: 1–102 (1942).Google Scholar
  64. 54a.
    Fleischer, G., Lennette, E. T., Henle, G., and Henle, W., Incidence of heterophile antibody responses in children with infectious mononucleosis, J. Pediatr. 94: 723–728 (1979).Google Scholar
  65. 55.
    Gardner, H. T., and Paul, J. R., Infectious mononucleosis at the New Haven Hospital, 1921–46, Yale J. Biol. Med. 19: 839–853 (1947).PubMedGoogle Scholar
  66. 56.
    Gerber, P., and Deal, D. R., Epstein-Barr virus-induced viral and soluble complement-fixing antigens in Burkitt lymphoma cell cultures, Proc. Soc. Exp. Biol. Med. 134: 748–751 (1970).PubMedGoogle Scholar
  67. 57.
    Gerber, P., and Rosenblum, E. N., The incidence of complement-fixing antibodies to herpes simplex and herpes-like viruses in man and rhesus monkeys, Proc. Soc. Exp. Biol. Med. 128: 541–546 (1968).PubMedGoogle Scholar
  68. 58.
    Gerber, P., Purcell, R. H., Rosenblum, E. N., and Walsh, J. H., Association of EB-virus infection with the post-perfusion syndrome, Lancet 1: 593–596 (1969).PubMedGoogle Scholar
  69. 59.
    Gerber, R., Goldstein, L. I., Lucas, S., Nonoyama, M., and Perlin, E., Oral excretion of Epstein-Barr viruses by healthy subjects and patients with infectious mononucleosis, Lancet 2: 988–989 (1972).PubMedGoogle Scholar
  70. 59a.
    Gerber, P., Nkrumah, F. K., Pritchett, R., and Kiefs, E., Comparative studies of Epstein-Barr virus strains from Ghana and the United States, Int. J. Cancer 17: 71–81 (1976).PubMedGoogle Scholar
  71. 59b.
    Ginsburg, C. M., Henle, W., Henle, G., and Horwitz, C. A., Infectious mononucleosis in children: Evaluation of Epstein-Barr virus specific serological data, J. Am. Med. Assoc. 237: 781–785 (1977).Google Scholar
  72. 59c.
    Ginsburg, C. M., Henle, G., and Henle, W., An outbreak of infectious mononucleosis among the personnel of an outpatient clinic, Am. J. Epidemiol. 104: 571–575 (1976).PubMedGoogle Scholar
  73. 60.
    Giulano, V. J., Jasin, H. E., and Ziff, M., The nature of the atypical lymphocyte in infectious mononu- cleosis, Clin. Immunol. Immunopathol. 3: 90–98 (1974).Google Scholar
  74. 61.
    Grace, J. T., Blakeslee, J., and Jones, R., Induction of infectious mononucleosis in man by the herpes-type virus (HTV) in Burkitt lymphoma cells in tissue culture, Proc. Am. Assoc. Cancer Res. 10: 31 (1969).Google Scholar
  75. 61a.
    Grose, C., Henle, W., Henle, G., and Feorino, P. M., Primary Epstein-Barr infections in acute neu- rologic disease, N. Engl. J. Med. 292: 392–393 (1975).PubMedGoogle Scholar
  76. 62.
    Haider, S., Coutinho, M. D., and Emond, R. T. D., Tuberculin anergy and infectious mononucleosis, Lancet 2: 74 (1973).PubMedGoogle Scholar
  77. 63.
    Hainebach, J., II. Beitrag zur Aetiologie des Pfeiffer’schen Drüsenfiebers, Dtsch. Med. Wochenschr. 26: 419–420 (1899).Google Scholar
  78. 64.
    Halcrow, J. P. A., Owen, L. M., and Roger, N. O., Infectious mononucleosis with an account of an epidemic in E.M.S. hospital, Br. Med. J. 2: 443–447 (1943).PubMedGoogle Scholar
  79. 65.
    Hallee, T. J., Evans, A. S., Niederman, J. C., Brooks, C. M., and Voegtly, J. H. Infectious mononucleosis at the U.S. Military Academy: A prospective study of a single class over four years, Yale J. Biol. Med. 47: 182–195 (1974).PubMedGoogle Scholar
  80. 65a.
    Hamilton, J. K., Sullivan, J. L., Maurer, H. S., Cruzi, F. G., Proirson, A. J., Stenke, K., Finkelstein, G. Z., Landing, B., Grunnet, M., and Purtilo, D. T., X-linked lymphoproliferative syndrome registry report, J. Pediatr. 4: 669–673 (1980).Google Scholar
  81. 66.
    Hampar, B., Hsu, K. C., Martos, L. M., and Walker, J. L., Serologic evidence that a herpes-type virus is the etiologic agent of heterophile-positive infectious mononucleosis, Proc. Natl. Acad. Sci. U.S.A. 68: 1407–1411 (1971).PubMedGoogle Scholar
  82. 67.
    Hardy, D. A., and Steel, C. M., Cytotoxic potential of lymphocytes stimulated with autochthonous lymphoid cell lines, Experientia 27: 1336–1338 (1971).PubMedGoogle Scholar
  83. 68.
    Heath, C. W., Brodsky, A. L., and Potolsky, A. I., Infectious mononucleosis in a general population, Am. J. Epidemiol. 95: 46–52 (1972).PubMedGoogle Scholar
  84. 68a.
    Haynes, B. F., Schooley, R. T., Playing-Wright, C. R., Grouse, J. E., Dolin, R., and Fauci, A. S. Emergence of suppressor cells of immunoglobulin synthesis during acute Epstein-Barr-virus-induced infectious mononucleosis, J. Immunol. 123: 2095–2101 (1979).PubMedGoogle Scholar
  85. 68b.
    Haynes, B. F., Schooley, R. T., Grouse, J. E., Playing-Wright, C. R., Dolin, R., and Fauci, A. S., Characterization of thymus-derived lymphocyte subsets in acute Epstein-Barr virus induced infectious mononucleosis, J. Immunol. 122: 699–702 (1979).PubMedGoogle Scholar
  86. 68c.
    Henderson, E., Miller, G., Robinson, J., and Heston, L., Efficiency of transformation of lymphocytes by Epstein-Barr virus, Virology 76: 152–163 (1977).PubMedGoogle Scholar
  87. 68d.
    Henderson, E., Heston, L., Grogan, E., and Miller, G., Radiobiological inactivation of Epstein-Barr virus, J. Virol. 25: 51–59 (1978).PubMedGoogle Scholar
  88. 69.
    Henke, C. E., Kurland, L. T., and Elveback, L. R., Infectious mononucleosis in Rochester, Minn., 1950 through 1969, Am. J. Epidemiol. 98: 483–490 (1973).PubMedGoogle Scholar
  89. 70.
    Henle, G., and Henle, W., Immunofluorescence in cells derived from Burkitt’s lymphoma, J. Bacterial. 91: 1248–1256 (1966).Google Scholar
  90. 71.
    Henle, G., and Henle, W., Observations on childhood infections with Epstein-Barr virus, J. Infect. Dis. 121: 303–310 (1970).PubMedGoogle Scholar
  91. 72.
    Henle, G., Henle, W., and Diehl, V., Relation of Burkitt’s tumor-associated herpes-type virus to infectious mononucleosis, Proc. Natl. Acad. Sci. U.S.A. 59: 94–101 (1968).PubMedGoogle Scholar
  92. 73.
    Henle, G., Henle, W., and Horwitz, C. A., Antibodies to Epstein-Barr virus-associated nuclear antigen in infectious mononucleosis, J. Infect. Dis. 130: 231–239 (1974).PubMedGoogle Scholar
  93. 73a.
    Henle, W., Henle, G., and Horwitz, C. A., Epstein-Barr virus specific diagnostic tests in infectious mononucleosis, Hum. Pathol. 5: 551–565 (1974).PubMedGoogle Scholar
  94. 74.
    Henle, G., Henle, W., and Klein, G., Demonstration of two distinct components in the early antigen complex of Epstein-Barr virus-infected cells, Int. J. Cancer 8: 272–282 (1971).PubMedGoogle Scholar
  95. 75.
    Henle, W., Henle, G., Harrison, F. S., Joyner, C. R., Klemola, E., Paloheimo, J., Scriba, M., and von Essen, F., Antibody responses to the Epstein-Barr virus and cytomegaloviruses after open-heart and other surgery, N. Engl. J. Med. 282: 1068–1074 (1968).Google Scholar
  96. 76.
    Henle, W., Henle, G., Pearson, G., Scriba, M., Waubke, R., and Zajac, B. A., Differential reactivity of human serums with early antigens induced by Epstein-Barr virus, Science 169: 188–190 (1970).PubMedGoogle Scholar
  97. 77.
    Henle, W., Henle, G., Niederman, J. C., Haltia, K., and Klemola, E., Antibodies to early antigens induced by Epstein-Barr virus in infectious mononucleosis, J. Infect. Dis. 124: 58–67 (1971).PubMedGoogle Scholar
  98. 78.
    Hewetson, J. F., Rochi, G., Henle, W., and Henle, G., Neutralizing antibodies to Epstein-Barr virus in healthy populations and patients with infectious mononucleosis, J. Infect. Dis. 128: 283–389 (1973).PubMedGoogle Scholar
  99. 79.
    Hoagland, R. J., The transmission of infectious mononucleosis, Am. J. Med. Sci. 229: 262–272 (1955).PubMedGoogle Scholar
  100. 80.
    Hoagland, R. J., Resurgent heterophil-antibody reaction after infectious mononucleosis, N. Engl. J. Med. 269: 1307–1308 (1963).PubMedGoogle Scholar
  101. 81.
    Hoagland, R. J., The incubation period of infectious mononucleosis, Am. J. Public Health 54: 1699–1705 (1964).Google Scholar
  102. 82.
    Hoagland, R., Infectious Mononucleosis, Grune and Stratton, New York, 1967.Google Scholar
  103. 83.
    Hobson, F. G., Lawson, B., and Wigfield, M., Glandular fever, a field study, Br. Med. J. 1: 845–852 (1958).PubMedGoogle Scholar
  104. 83a.
    Hoskins, T. W., Fletcher, W. B., Blake, J. M., Pereira, M. S., and Edwards, J. M. B., EB virus antibody and infectious mononucleosis in a boarding school for boys, J. Clin. Pathol. 29: 42–45 (1976).PubMedGoogle Scholar
  105. 83b.
    Him, L. M., Huang, Y. T., Dascomb, H. E., and Pagano, J. S., Enhanced destruction of lymphoid cell lines by peripheral blood leucocytes taken from patients with acute infectious mononucleosis, J. Immunol. 115: 243–248 (1975).Google Scholar
  106. 84.
    Jennings, E., Prevalence of EB virus antibody in Hawaii, M.D. thesis, Yale University School of Medicine, 1973.Google Scholar
  107. 85.
    Joncas, J., and Mitnyan, C., Serological response of the EBV antibodies in pediatric cases of infectious mononucleosis and in their contacts, Can. Med. Assoc. J. 102: 1260–1263 (1970).PubMedGoogle Scholar
  108. 85a.
    Jondal, M., and Klein, G., Surface markers on human B and T lymphocytes. II. Presence of Epstein-Barr virus receptors on B lymphocytes, J. Exp. Med. 138: 1365–1378 (1973).PubMedGoogle Scholar
  109. 85b.
    Jondal, M., Klein, G., Oldstone, M. B. S., Bokish, V., and Yefenof, E., Surface markers on human B and T lymphocytes. VII. Association between complement and Epstein-Barr virus receptors on human lymphoid lines, Scand. J. Immunol. 5: 401–410 (1976).PubMedGoogle Scholar
  110. 86.
    Jordan, W. S., and Albright, R. W., Liver function tests in infectious mononucleosis, J. Lab. Clin. Med. 35: 688–698 (1950).PubMedGoogle Scholar
  111. 87.
    Junge, U., Deinhardt, F., and Hoekstra, J., Stimulation of peripheral lymphocytes by allogeneic and autochthonous mononucleosis lymphocyte cell lines, J. Immunol. 106: 1306–1315 (1971).PubMedGoogle Scholar
  112. 87a.
    Kano, K., and Milgrom, F., Heterophile antigens and antibodies in medicine, Current Top. Microbiol. Immunol. 77: 43–69 (1977).Google Scholar
  113. 88.
    Klein, G., Klein, E., Clifford, P., and Sternsward, G., Search for tumor specific immune reactors in Burkitt lymphoma patients by the membrane immunofluorescence reaction, Proc. Natl. Acad. Sci. U.S.A. 55: 1628–1635 (1966).PubMedGoogle Scholar
  114. 88a.
    Kassl, S. V., Evans, A. S., and Niederman, J. C. Psychosocial risk factors in the development of infectious mononucleosis, Psychosom. Med. 41: 445–466, 1979.Google Scholar
  115. 89.
    Klein, G., Lindahl, T., Jondal, M., Leibolb, W., Menézes, J, Nilsson, K., and Sundström, C., Continuous lymphoid cell lines with characteristics of B cells (bone-marrow-derived) lacking the Epstein-Barr virus genome, and derived from three human lymphomas, Proc. Natl. Acad. Sci. U.S.A. 71: 3283–3286, (1974).PubMedGoogle Scholar
  116. 90.
    Klein, G., Diehl, V., Henle, G., Henle, W., Pear-Son, G., and Neiderman, J. C., Relations between Epstein-Barr viral and cell membrane immunofluorescence in Burkitt tumor cells. II. Comparison of cells and sera from patients with Burkitt’s lymphoma and infectious mononudeosis, J. Exp. Med. 128: 1021–1030 (1968).PubMedGoogle Scholar
  117. 90a.
    Klein, G., Svedmvy, E., Jondal, M., and Persson, P. O., EBV-determined nuclear antigen (EBNA)-positive cells in the peripheral blood of infectious mononucleosis patients, Int. J. Cancer 17: 21–26 (1976).PubMedGoogle Scholar
  118. 91.
    Klemola, E., Henle, G., Henle, W., and von Essen, R., Infectious mononucleosis-like disease with negative heterophile agglutination test: Clinical features in relation to Epstein-Barr virus and cytomegalovirus antibodies, J. Infect. Dis. 121: 608–614 (1970).PubMedGoogle Scholar
  119. 92.
    Lang, D. J., and Hanshaw, J. B., Cytomegalovirus infection and the postperfusion syndrome: Recognition of primary infection in four patients, N. Engl. J. Med. 280: 1145–1149 (1969).PubMedGoogle Scholar
  120. 93.
    Lee, C. L., Davidsohn, I., and Slaby, R., Horse agglutinins in infectious mononucleosis. Am. J. Clin. Pathol. 49: 3–11 (1968).PubMedGoogle Scholar
  121. 94.
    Lehane, D. E., A seroepidemiologic study of infectious mononucleosis: The development of EB virus antibody in a military population, J. Am. Med. Assoc. 212: 2240–2242 (1970).Google Scholar
  122. 94a.
    Lemon, S. M., Hun, L. M., Shaw, J. C., Li, J. H., and Pagano, J. H., Replication of EBV in epithelial cells during infectious mononucleosis, Nature (London) 268: 268–270 (1977).Google Scholar
  123. 94b.
    Lemon, S. M., Hutt, L. M., Huang, Y., Bhum, J., and Pagano, J. H., Simultaneous infection with multiple herpesviruses, Am. J. Med. 66: 270–276 (1979).PubMedGoogle Scholar
  124. 94c.
    Lennette, E. T., Henle, G., Henle, W., and Horowitz, C. A., Heterophil antigen in bovine sera detectable by immune adherence hemagglutination with infectious mononucleosis sera, Infect. Immun. 19: 923–927 (1978).PubMedGoogle Scholar
  125. 95.
    Liebowitz, S., Infectious Mononucleosis, Grune and Stratton, New York, 1953.Google Scholar
  126. 96.
    Longcope, W. T., Infectious mononucleosis (glandular fever), with a report of ten cases, Am. J. Med. Sci. 164: 781–807 (1922).Google Scholar
  127. 97.
    Mangi, R., Niederman, J. C., Kelleher, J. E., Dwyer, J. M., Evans, A. S., and Kantor, F. S., Depression of cell-mediated immunity during acute infectious mononucleosis, N. Engl. J. Med. 291: 1149–1153 (1974).PubMedGoogle Scholar
  128. 98.
    Mason, K. L., Anoxcell hemolysin test for the diagnosis of infectious mononucleosis, J. Hyg. 49: 471–481 (1951).Google Scholar
  129. 99.
    Maurer, B. A., Imamura, T., and Wilbert, S. M., Incidence of EB virus containing cells in primary and secondary clones of several Burkitt lymphoma cell lines, Cancer Res. 30: 2870–2875 (1970).PubMedGoogle Scholar
  130. 100.
    Miller, G., The oncogenicity of Epstein-Barr virus, J. Infect. Dis. 130: 187–205 (1974).PubMedGoogle Scholar
  131. 100a.
    Miller, G., Biology of Epstein-Barr virus, in: Viral Oncology (G. Klein, ed.), pp. 713–738, Raven Press, New York, 1980.Google Scholar
  132. 101.
    Miller, G., and Heston, L., Expression of Epstein-Barr viral capsid, complement fixing and nuclear antigens in stationary and exponential phase cultures, Yale J. Biol. Med. 47: 123–135 (1974).PubMedGoogle Scholar
  133. 102.
    Miller, G., and Lipman, M., Release of infectious Epstein-Barr virus by transformed marmoset leucocytes, Proc. Natl. Acad. Sci. U.S.A. 70: 190–194 (1973).PubMedGoogle Scholar
  134. 103.
    Miller, G., Niederman, J. C., and Andrews, L. L., Prolonged oropharyngeal excretion of Epstein-Barr virus after infectious mononucleosis, N. Engl. J. Med. 288: 229–232 (1973).PubMedGoogle Scholar
  135. 104.
    Miller, G., Miller, M. H., and Stitt, D., Epstein-Barr viral antigen in single cell clones of two human leucocytic lines, J. Virol. 6: 699–701 (1970).PubMedGoogle Scholar
  136. 105.
    Miller, G., Niederman, J. C., and Stitt, D. A., Infectious mononucleosis: Appearance of neutralizing antibody to Epstein-Barr virus measured by inhibition of formation of lymphoblastoid cell lines, J. Infect. Dis. 125: 403–406 (1972).PubMedGoogle Scholar
  137. 106.
    Miller, G., Robinson, J., Heston, L., and Lipman, M., Differences between laboratory strains of Epstein-Barr virus based on immortalization, abortive infection and interference, Proc. Natl. Acad. Sci. U.S.A. 71: 4006–4010 (1974).PubMedGoogle Scholar
  138. 107.
    Moir, J. I., Glandular fever in the Falkland Islands, Br. Med. J. 2: 822–823 (1930).Google Scholar
  139. 107a.
    Mori, T., Kano, K., and Milgrom, F., Formation of Paul Bunnell antibodies by cultures of lymphocytes from infectious mononucleosis, Cell. Immunol. 34: 289–298 (1977).PubMedGoogle Scholar
  140. 107b.
    Morgan, D. G., Niederman, J. C., Miller, G., Smith, H. W., and Dowaliby, J. M., Site of Epstein-Barr virus replication in the oropharynx, Lancet 2: 1154–1157 (1979).PubMedGoogle Scholar
  141. 108.
    Morse, P. F., Glandular fever, J. Am. Med. Assoc. 77: 1403–1404 (1921).Google Scholar
  142. 108a.
    Munoz, N., Davidson, R. J. K., Witthoff, B., Ericsson, J. E., and De The, G., Infectious mononucleosis and Hodgkin’s disease, Int. J. Cancer 22: 10–13 (1978).PubMedGoogle Scholar
  143. 109.
    Newall, K. W., The reported incidence of glandular fever, and analysis of a report of the Public Health Laboratory Service, J. Clin. Pathol. 10: 20–22 (1957).Google Scholar
  144. 110.
    Niederman, J. C., Infectious mononucleosis at the Yale-New Haven Medical Center, 1946–1955, Yale J. Biol. Med. 28: 629–643 (1956).PubMedGoogle Scholar
  145. 111.
    Niederman, J. C., The presence of EBV antibody in sera from volunteers in infectious mononucleosis transmission attempts prior to inoculation, Unpublished work (1969).Google Scholar
  146. 112.
    Niederman, J. C., and Scott, R. B., Studies on infectious mononucleosis: Attempts to transmit the disease to human volunteers, Yale J. Biol. Med. 38: 1–10 (1965).PubMedGoogle Scholar
  147. 113.
    Niederman, J. C., Evans, A. S., Mccollum, R. W., and Subrahmanyan, L., Prevalence, incidence and persistence of EB virus antibody in young adults, N. Engl. J. Med. 282: 361–365 (1970).PubMedGoogle Scholar
  148. 114.
    Niederman, J. C., Mccollum, R. W., Henle, G., and Henle, W., Infectious mononucleosis: Clinical manifestations in relation to EB virus antibodies, J. Am. Med. Assoc. 203: 205–209 (1968).Google Scholar
  149. 114a.
    Niederman, J. C., Miller, G., Pearson, H. A., Pagano, J. S., and Dowaliby, J. M., Infectious mononucleosis: Epstein-Barr shedding in saliva and the oropharynx, N. Engl. J. Med. 294: 1355–1359 (1976).PubMedGoogle Scholar
  150. 114b.
    Nikoskelainen, J., Leikola, J., and Klemola, E., IgM antibodies specific for Epstein-Barr virus in infectious mononucleosis without heterophile antibodies, Br. Med. J. 4: 72–75 (1974).PubMedGoogle Scholar
  151. 114c.
    Nikoskelainen, J. J., Ablashi, D. V., Isenberg, R. A., Neel, E. U., Miller, R. G., and Stevens, D. A., Cellular immunity in infectious mononucleosis. II. Specific reactivity to Epstein-Barr virus antigens and correlation with clinical and hematologic parameter, 1. Immunol. 121: 1239–1244 (1978).Google Scholar
  152. 115.
    Nonoyama, M., and Pagano, J. S., Homology between Epstein-Barr virus DNA and viral DNA from Burkitt’s lymphoma and nasopharyngeal carcinoma determined by DNA-DNA reassociation kinetics, Nature (London) 242: 44–47 (1973).Google Scholar
  153. 116.
    Old, L. J., Clifford, P., Boyse, E. A., Deharven, E., Geering, G., Oettgen, H. F., and Williamson, B., Precipitating antibody in human serum to an antigen present in cultured Burkitt lymphoma cells, Proc. Natl. Acad. Sci. U.S.A. 56: 1699–1704 (1966).PubMedGoogle Scholar
  154. 117.
    Pagano, J. S., The Epstein-Barr viral genome and its interactions with human lymphoblastoid cells and chromosomes, in: Viruses, Evolution and Cancer (K. Maramorosch and E. Kurstak, eds.), 79–116, Academic Press, New York, 1974.Google Scholar
  155. 117a.
    Pannuti, C. S., Carvalho, R. P. S., Evans, A. S., Cenabre, L. C., Neto, A., Camargo, M., Angelo, M. J. P., and Takimoto, S., A prospective clinical study of the mononucleosis syndrome in a developing country, Int. J. Epidemiol. 9: 349–353 (1980).PubMedGoogle Scholar
  156. 118.
    Pattengale, P. K., Gerber, P., and Smith, R. W., Selective transformation of B lymphocytes by EB virus, Lancet 2: 1153–1155 (1973).Google Scholar
  157. 119.
    Pattengale, P. K., Gerber, P., and Smith, R. W., Bcell characteristics of human peripheral and cord blood lymphocytes transformed by Epstein-Barr virus, J. Natl. Cancer Inst. 52: 1081–1086 (1974).PubMedGoogle Scholar
  158. 120.
    Pattengale, P. K., Smith, R. W., and Perlin, E., Atypical lymphocytes in acute infectious mononucleosis, N. Engl. J. Med. 291: 1145–1148 (1974).PubMedGoogle Scholar
  159. 121.
    Paul, J. R., and Bunnell, W. W., The presence of heterophile antibodies in infectious mononucleosis, Am. J. Med. Sci. 183: 91–104 (1932).Google Scholar
  160. 122.
    Paul, O., Mononucleosis on board a destroyer, U.S. Naval Med. Bull. 44: 614–617 (1945).Google Scholar
  161. 123.
    Pearson, G., Dewey, F., Klein, G., Henle, G., and Henle, W., Relation between neutralization of Epstein-Barr virus and antibodies to cell membrane antigens induced by the virus, J. Natl. Cancer Inst. 45: 989–995 (1970).PubMedGoogle Scholar
  162. 124.
    Pereira, M. S., Blake, J. M., and Macrae, A. D., EB virus antibody at different ages, Br. Med. J. 4: 526–527 (1969).PubMedGoogle Scholar
  163. 125.
    Pereira, M. S., Field, A. M., Blake, J. M., Rodgers, F. G., Bailey, L. A., and Davies, J. R., Evidence for oral excretion of E.B. virus in infectious mononucleosis, Lancet 1: 710–711 (1972).PubMedGoogle Scholar
  164. 126.
    Pfeiffer, E., Drosenfieber, Jahrb. Kinderheilkd. 29: 257–264 (1889).Google Scholar
  165. 127.
    Pope, J. H., Horne, M. K., and Wetters, E. J., Significance of a complement-fixing antigen associated with herpes-like virus and detected in the Raji cell line, Nature (London) 228: 186–187 (1969).Google Scholar
  166. 128.
    Pulvertaft, R. J. X., Cytology of Burkitt’s tumor (African lymphoma), Lancet 1: 238–240 (1964).PubMedGoogle Scholar
  167. 128a.
    Purtilo, D. T., Bhawan, J., Him, L. M., De Nicola, L., Szymanski, I., Yang, J. P. S., Boto, W., Maier, R., and Thorley-Lawson, D., Epstein-Barr virus infections in the X-linked recessive lymphoproliferative syndrome, Lancet 1: 798–801 (1978).PubMedGoogle Scholar
  168. 128b.
    Purtilo, D. T., Hutt, L, Bhawan, J., Yang, J. P. S., Cassel, C., Allegro, S., and Rosen, F. S., Immunodeficiency to the Epstein-Barr virus in the X-linked recessive lymphoproliferative syndrome, Clin. Immunol. Immunopathol. 9: 147–156 (1978).PubMedGoogle Scholar
  169. 128c.
    Qualtiere, L. F., and Pearson, G. R., Solubilization of Epstein-Barr virus induced membrane antigen by limited papain digestion, Fed. Proc. Fed. Am. Soc. Exp. Biol. 37: 1817 (1978).Google Scholar
  170. 129.
    Reedman, B. M., and Klein, G., Cellular localization of an Epstein-Barr virus (EBV) associated complement-fixing antigen in producer and non-producer lymphoblastoid cell lines, Int. J. Cancer 11: 499–520 (1973).PubMedGoogle Scholar
  171. 129a.
    Robinson, J., and Miller, G., Assay for Epstein-Barr virus based on stimulation of DNA synthesis in mixed leukocytes from human umbilical cord blood, J. Virol. 15: 1065–1072 (1975).PubMedGoogle Scholar
  172. 129b.
    Robinson, J. E., Brown, N., Andiman, W., Halliday, K., Francke, U., Robert, M. F., Anderssonanvret, M., Horstmann, D., and Miller, G., Diffuse polyclonal B-cell lymphoma during primary infection with Epstein-Barr virus, New Engl. J. Med. 320: 1293–1296 (1980).Google Scholar
  173. 130.
    Rocchi, G., Hewetson, J., and Henle, W., Specific neutralizing antibodies in Epstein-Barr virus asso-dated diseases, Int. J. Cancer 11: 637–647 (1973).PubMedGoogle Scholar
  174. 130a.
    Rocchi, G., De Felici, A., Ragona, G., and Heinz, A., Quantitative evaluation of Epstein-Barr-virusinfected mononuclear peripheral blood leukocytes in infectious mononucleosis, N. Engl. J. Med. 296: 132–134 (1977).PubMedGoogle Scholar
  175. 131.
    Rosalki, S. B., Lwynn, J. T., and Verney, P. T., Transaminase and liver function studies in infectious mononucleosis, Br. Med. J. 1: 929–932 (1960).PubMedGoogle Scholar
  176. 131a.
    Rosdahl, N., Larsen, S. O., and Thamdrup, B., Infectious mononucleosis in Denmark: Epidemiological observations based on positive Paul-Bunnell reactions 1940–1969, Scand. J. Infect. Dis. 5: 163–170 (1973).PubMedGoogle Scholar
  177. 131b.
    Rosen, A., Gergely, P., Jondal, M., and Klein, G., Polyclonal Ig production after Epstein Barr virus infection of human lymphocytes in vitro, Nature (London) 267: 52 (1977).Google Scholar
  178. 131c.
    Royston, I., Sullivan, J. L., Periman, P. O., and Perlin, E., Cell-mediated immunity to Epstein-Barr virus-transformed lymphoblastoid cells in acute infectious mononucleosis, N. Engl. J. Med. 293: 1159–1163 (1975).PubMedGoogle Scholar
  179. 132.
    Sawyer, R. N., Evans, A. S., Niederman, J. C., and McCollum, R. W., Prospective studies of a group of Yale University freshmen. I. Occurrence of infectious mononucleosis, J. Infect. Dis. 123: 263–269 (1971).PubMedGoogle Scholar
  180. 132a.
    Schiff, J., Schaeffer, J., and Robinson, J., Cell-associated Epstein-Barr virus in the cerebrospinal fluid of a patient with meningoencephalitis complicating infectious mononudeosis, Personal communication (1978).Google Scholar
  181. 132b.
    Schiller, J., and Davey, F. R., Human leukocyte locus A (HL-A antigens and infectious mononucleosis, Am. J. Clin. Pathol. 62: 325–328 (1974).PubMedGoogle Scholar
  182. 133.
    Schmitz, H., and Scherer, M., IgM antibodies to Epstein-Barr virus in infectious mononucleosis, Arch. Gesamte Virusforsch. 37: 332–339 (1972).PubMedGoogle Scholar
  183. 134.
    Sheldon, P. J., Hemsted, E. H., Holborow, E. J., and Papamichael, M., Thymic origin of atypical lymphocytes in infectious mononucleosis, Lancet 2: 1153–1155 (1973).Google Scholar
  184. 135.
    Shope, T., and Miller, G., Epstein-Barr virus, heterophile responses in squirrel monkeys inoculated with virus-transformed autologous leucocytes, J. Exp. Med. 137: 140–147 (1973).PubMedGoogle Scholar
  185. 136.
    Shope, T., Evans, A. S., and Horstmann, D. M., Seroconversion rates of EBV antibody in New Haven school children by socio-economic level, Unpublished studies (1973).Google Scholar
  186. 136a.
    Smith, H., and Denman, A. M., A new manifestation of infection with Epstein-Barr virus, Br. Med. J. 2: 248–249 (1978).PubMedGoogle Scholar
  187. 137.
    Sohier, R., Lepine, P., and Sautter, V., Recherches sur la transmission experimentale de la mononucleose au singe et a l’homme, Ann. Inst. Pasteur 65: 50–62 (1940).Google Scholar
  188. 138.
    Sohier, R., La Mononucleose Infectieuse, Masson et Cie, Paris, 1943.Google Scholar
  189. 139.
    Sprunt, T. P., and Evans, F. A., Mononuclear leukocytosis in reaction to acute infections (in infectious mononucleosis), Bull. Johns Hopkins Hosp. 31: 410–417 (1920).Google Scholar
  190. 140.
    Steel, C. M., and Ling, N. R., Immunopathology of infectious mononucleosis, Lancet 2: 861–862 (1973).Google Scholar
  191. 141.
    Stevenson, E. M. K., and Brown, T. G., Infectious mononucleosis: Preliminary investigation of a series of cases, Glasgow Med. J. 140: 139–150 (1943).Google Scholar
  192. 142.
    Storrie, M. D., Sawyer, R. N., Sphar, R. L., and Evans, A. S., Seroepidemiological studies of Polaris submarine crews. II. Infectious mononucleosis, Mil. Med. 141: 30–33 (1976).PubMedGoogle Scholar
  193. 143.
    Strauch, B., Andrews, L., Miller, G., and Siegel, N., Oropharyngeal excretion of Epstein-Barr virus by renal transplant recipients and other patients treated with immunosuppressant drugs, Lancet 1: 234–237 (1974).PubMedGoogle Scholar
  194. 144.
    Ström, J., Infectious mononucleosis-Is the incidence increasing?, Acta Med. Scand. 168: 35–39 (1960).Google Scholar
  195. 144a.
    Sumaya, C. V., Primary Epstein-Barr virus infec- tions in children, Pediatrics 59: 16–21 (1977).PubMedGoogle Scholar
  196. 145.
    Taylor, A. W., Effects of glandular fever in acute leukemia, Br. Med. J. 1: 589–593 (1953).PubMedGoogle Scholar
  197. 146.
    Thomsen, S., Studier over Mononucleosis Infectiosa, Munksgaard, Copenhagen, 1942.Google Scholar
  198. 146a.
    Thorley-Lawson, D. A., Chess, L., and Strominger, J. L., Suppression of in vitro Epstein-Barr virus infection: A new role for adult human T lymphocytes, J. Exp. Med. 146: 495–507 (1977).PubMedGoogle Scholar
  199. 147.
    Tischendorf, P., Balagtas, R. C., Deinhardt, F., Knospe, W. H., Maynard, J. E., Noble, G. R., and Shramek, G. J., Development and persistence of immunity to Epstein-Barr virus in man, J. Infect. Dis. 122: 401–409 (1970).PubMedGoogle Scholar
  200. 147a.
    Tosato, G., Magrath, I., Koski, I., Dooley, N., and Blaese, M., Activation of suppressor T cells during Epstein-Barr-virus induced infectious mononucleosis, N. Engl. J. Med. 301: 1133–1137 (1979).PubMedGoogle Scholar
  201. 148.
    University Health Physicians and P.H.L.S. Laboratories, A joint investigation: Infectious mononucleosis and its relationship to EB virus antibody, Br. Med. J. 4: 643–646 (1971).Google Scholar
  202. 149.
    Vandermeer, R., Lutterloh, C. H., and Pilot, J. Infectious mononucleosis: An analysis of 26 clinical and 340 subclinical cases, Am. J. Med. Sci. 210: 765–774 (1945).Google Scholar
  203. 149a.
    Veltri, R. W., Mcclung, J. E., and Sprinkle, P. M., EBV antigens in lymphocytes of patients with exudative tonsillitis, infectious mononucleosis and Hodgkin’s disease, Int. J. Cancer 21: 683–687 (1978).PubMedGoogle Scholar
  204. 149b.
    Veltri, R. W., Mcclung, J. E., and Sprinkle, P. M., Epstein-Barr nuclear antigen (EBNA) carrying lymphocytes in human palatine tonsils, J. Gen. Virol. 32: 455–460 (1976).PubMedGoogle Scholar
  205. 149c.
    Visintine, A. M., Gerber, P., and Nahmias, A. J., Leucocyte transforming agent (Epstein-Barr virus) in newborn infants and older individuals, J. Pediatr. 89: 571–575 (1976).PubMedGoogle Scholar
  206. 150.
    Virolainen, M., Anderson, L. C., Lalla, M., and von Essen, R., T-lymphocyte proliferation in mononucleosis, Clin. Immunol. Immunopathol. 2: 114–120 (1973).PubMedGoogle Scholar
  207. 151.
    Wahren, B., Espmark, A., Lantorp, K., and Sterner, G., EBV antibodies in family contacts of patients with infectious mononucleosis, Proc. Soc. Exp. Biol. Med. 133: 934–939 (1970).PubMedGoogle Scholar
  208. 152.
    Walters, M. K., and Pope, J. H., Studies of the EB virus-related antigens of human leucocyte cell lines, Int. J. Cancer 8: 32–40 (1971).PubMedGoogle Scholar
  209. 153.
    Wechsler, H. F., Rosenblum, A. H., and Sills, C. T., Infectious mononucleosis: Report of an epidemic in an army post, Ann. Intern. Med. 25:113–133, 236–265 (1946).Google Scholar
  210. 154.
    Werner, J., Haff, R. F., Henle, G., Henle, W., and Pinto, C. A., Responses of gibbons to inoculation of Epstein-Barr virus, J. Infect. Dis. 126: 678–681 (1972).PubMedGoogle Scholar
  211. 154a.
    Yefenof, E., Bakacs, T., Einhorn, L., Ernberg, I., and Kelin, G., Epstein-Barr virus (EBV) receptors, complement receptors and EBV infectibility of different lymphocyte fractions of human peripheral blood, Cell. Immunol. 35: 34–42 (1978).PubMedGoogle Scholar
  212. 155.
    West, J. P., An epidemic of glandular fever, Arch. Pediatr. 13: 889–900 (1896).Google Scholar
  213. 156.
    Wising, P. J., A study of infectious mononucleosis (Pfeiffer’s disease) from the etiological point of view, Acta Med. Scand. Suppl. 133: 1–102 (1942).Google Scholar
  214. 157.
    Wöllner, D., Ueber die serologische Diagnose der infektiosen Mononukleose nach Paul-Bunnell mit nativen and fermentierten Hammel Erythrocyten. 2, Immunitaets Forsch. 112: 290–308 (1955).Google Scholar
  215. 158.
    Wroblewski, F., Increasing clinical significance of alterations in enzymes in body fluids, Ann. Intern. Med. 50: 62–93 (1959).PubMedGoogle Scholar
  216. 159.
    Zajac, B. A., and Kohn, G., Epstein-Barr virus antigens, marker chromosomes, and interferon production in clones derived from cultured Burkitt tumor cells, J. Natl. Cancer Inst. 45: 399–406 (1970).PubMedGoogle Scholar
  217. 160.
    Zur Hausen, H. H., Clifford, P., Henle, G., Henle, W., Klein, G., Santesson, L., and Schulte-Holthausen, H., EB-virus DNA in biopsies of Burkitt tumors and anaplastic carcinomas of the nasopharynx, Nature (London) 228: 1056–1057 (1970).Google Scholar
  218. 161.
    Zur Hausen, H., Dorrier, K., Egger, H., Schulteholthausen, H., and Wolf, H., Attempts to detect virus-specific DNA in human tumors. II. Nucleic add hybridizations with complementary RNA of human herpes group viruses, Int. J. Cancer 13: 657–664 (1974).PubMedGoogle Scholar

Suggested Reading

  1. Carter, R. L., and Penman, H. G. (eds.), Infectious Mononucleosis, Blackwell, Oxford, 1969.Google Scholar
  2. Chervenick, P. A., Infectious mononucleosis, Dis.-Mon. 1–56 (December 1974).Google Scholar
  3. Evans, A. S., Infectious mononucleosis and related syndromes, Am. J. Med. Sci. 276: 325–339 (1978).PubMedGoogle Scholar
  4. Glade, P. R. (ed.), Infectious Mononucleosis, Lippincott, Philadelphia, 1973.Google Scholar
  5. Henle, W., and Henle, G., Epstein—Barr virus, Sci. Am. 241: 48–59 (1979).PubMedGoogle Scholar
  6. Hoagland, R., Infectious Mononucleosis, Grune and Stratton, New York, 1967.Google Scholar
  7. Klein, G., The Epstein—Barr Virus in Herpesviruses (A. S. Kaplan, ed.), Academic Press, New York, 1973.Google Scholar
  8. Miller, G., Epstein—Barr virus and infectious mononucleosis, Prog. Med. Virol. 20: 84–112 (1975).PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1984

Authors and Affiliations

  • Alfred S. Evans
    • 1
  • James C. Niederman
    • 2
  1. 1.WHO Serum Reference Bank, Section of International Epidemiology, Department of Epidemiology and Public HealthYale University School of MedicineNew HavenUSA
  2. 2.Department of Epidemiology and Public HealthYale University School of MedicineNew HavenUSA

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