Photoradiation for Choroidal Malignant Melanoma
Photoradiation therapy is the pretreatment of tissue with a photo sensitizing substance followed by exposure to light energy, resulting in a photodynamic reaction that causes cell death. This concept has been investigated since the early 1900s without success until the 1970s. At this time, Dougherty (1978; 1979; 1981) and his group at Roswell Park, New York developed a derivative of hematoporphyrin (HpD) that appears to meet the necessary criteria of a photoradiation therapy. It is well known that the HpD, when given to patients, is concentrated in neoplastic tissue to a greater extent than in normal tissues. Exposure of the sensitized tissue to red light (630 nm) results in a photodynamic reaction, causing oxidation of cross linkages in the cell wall resulting in cell lysis (Moan et al., 1979; Weishaupt et al., 1976). To date, many types of human and animal neoplasms have been responsive to this mode of therapy (McBride, 1979).
KeywordsVisual Acuity Tumor Mass Fluorescein Angiography Vitreous Hemorrhage Choroidal Malignant Melanoma
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