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On the Purification of Hematoporphyrin IX and its Acetylated Derivatives

  • Daniel Brault
  • Christine Bizet
  • Olavio Delgado

Abstract

Hematoporphyrin IX (Hp, Fig. 1a) and especially the related product known as “Hematoporphyrin Derivative or HpD” have been the most used compounds in tumor diagnostic and phototherapy as outlined during this symposium. Also, hematoporphyrin is one of the most common photosensitizer. This situation is disquieting because of the general uncertainty about the purity of hematoporphyrin1 The major impurities of the commercial product are 8(3)-(1-hydro-xyethyl)-3(8)-vinyldeuteroporphyrin (HVD, 2 isomers, Fig. 1b), protoporphyrin (PP, Fig. 1c) and unidentified brown impurities.

Keywords

General Uncertainty Chloroformic Phase Major Impurity Eluent Flow Rate Hematoporphyrin Derivative 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Daniel Brault
    • 1
  • Christine Bizet
    • 1
  • Olavio Delgado
    • 1
  1. 1.Laboratoire de Biophysique, INSERM U.201, CNRS ERA 951Muséum National d’Histoire NaturelleParisFrance

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