Abstract
Hematoporphyrin derivative photoradiation therapy is an effective therapeutic modality for several types of solid tumors 1,2. One area of recent clinical interest is the exploitation of HpD PRT for the treatment of ocular malignancies 3,4. New therapies which can provide effective tumor destruction and minimal normal ocular tissue damage are needed since the current modalities used for treating eye tumors (external beam radiation, radioisotope plaques, photocoagulation and cryotherapy) are not totally satisfactory 5,6. HpD PRT may provide a modality which can be utilized for the treatment of both retinoblastoma and uveal melanoma. In addition, this procedure may be useful as both a primary modality in selective instances as well as a secondary modality following recurrence.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
T.J. Dougherty, J.B. Kaufman, A. Goldfarb, K.R. Weishaupt, D.G. Boyle, and A. Mittleman, Photoradiation therapy for the treatment of malignant tumors, Cancer Res. 38:2628–2635. (1978).
T.J. Dougherty, K.R. Weishaupt, and D.G. Boyle, “Photosensitizers” in: (eds., De Vita, V., S. Helman, and S. Rosenberg), Cancer, Principles and Practices of Oncology, pp. 1836–1844, Philadelphia: J.B. Lippincott Co., (1982).
C.J. Gomer, D.R. Doiron, J.V. Jester, B.C. Szirth, and A.L. Murphree, Hematoporphyrin derivative photoradiation therapy for the treatment of intraocular tumors: Examination of acute ocular tissue toxicity. Cancer Res. 43:721–727, (1983).
C.J. Gomer, D.R. Doiron, L. White, J.V. Jester, S. Dunn, B.C. Szirth, N.J. Razum, and A.L. Murphree, Hematoporphyrin derivative photoradiation induced damage to normal and tumor tissue of the pigmented rabbit eye. Current Eye Res., (In Press).
L.W. Brady, J.A. Shields, J.J. Augsburger, and J.L. Day, Malignant intraocular tumor. Cancer (Phila.) 49:578–585, (1982).
J.A. Shields, and J.J. Augsburger, Current approaches to the diagnosis and management of retinoblastoma. Surv. Ophthalmol. 25:347–372, (1981).
D.L. Krohn, R. Jacobs, and D.A. Morris, Diagnosis of model choroid malignant melanoma by hematoporphyrin derivative fluorescence in rabbits. Invest. Ophthalmol. 13:244–255, (1974).
S. Lerman, M. Jocoy, and R.F. Borkman, Photosensitization of the lens by 8-methoxypsoralen. Invest. Ophthalmo1. 16:1065–1068, (1977).
S. Lerman, and R.F. Borkman, Spectroscopic evaluation and classification of the normal, aging and cataractous lens. Ophthalmic. Res. 8:335–353, (1976).
R.S. Smith, and M.N. Stein, Ocular hazards of transcleral laser radiation. Am. J. Ophthalmol. 66:21–31, (1968).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1984 Plenum Press, New York
About this chapter
Cite this chapter
Gomer, C.J., Murphree, A.L., Doiron, D.R., Szirth, B.C., Razum, N.J. (1984). Preclinical Examination of Ocular Photoradiation Therapy. In: Andreoni, A., Cubeddu, R. (eds) Porphyrins in Tumor Phototherapy. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4721-7_49
Download citation
DOI: https://doi.org/10.1007/978-1-4684-4721-7_49
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-4723-1
Online ISBN: 978-1-4684-4721-7
eBook Packages: Springer Book Archive