Preclinical Examination of Ocular Photoradiation Therapy
Hematoporphyrin derivative photoradiation therapy is an effective therapeutic modality for several types of solid tumors 1,2. One area of recent clinical interest is the exploitation of HpD PRT for the treatment of ocular malignancies 3,4. New therapies which can provide effective tumor destruction and minimal normal ocular tissue damage are needed since the current modalities used for treating eye tumors (external beam radiation, radioisotope plaques, photocoagulation and cryotherapy) are not totally satisfactory 5,6. HpD PRT may provide a modality which can be utilized for the treatment of both retinoblastoma and uveal melanoma. In addition, this procedure may be useful as both a primary modality in selective instances as well as a secondary modality following recurrence.
KeywordsFluorescein Angiography Uveal Melanoma Fundus Photography Ocular Toxicity Retinal Edema
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