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Photoradiation Therapy with Hematoporphyrin Derivative and an Argon Dye Laser of Bladder Carcinoma

  • Tetsutaro Ohi
  • Harubumi Kato
  • Akira Tsuchiya
  • Nobuo Obara
  • Koichi Imamura
  • Katsuo Aizawa
  • Chimori Konaka
  • Jutaro Ono
  • Norihiko Kawate
  • Kazuo Yoneyama
  • Makoto Saito
  • Hidenobu Takahashi
  • Sumiyaki Tsukimura
  • Hideki Shinohara
  • Johnson Lay
  • Yoshihiro Hayata

Abstract

Hematoporphyrin Derivative (HpD) which has an affinity for malignant tumors is excited by light exposure and reacts photodynamically in tumor tissue. Therefore it is possible to treat malignant tumor selectively without any damage to surrounding normal tissues. HpD is excited by a light in the spectrum from ultraviolet to visible red. Previously arc lamps and slide projectors were used for excitation of HpD but laser beams which facilitate photoradiation via endoscopes has been used recently. Much of the early basic and clinical studies on HpD and light photoradiation therapy was performed by Dougherty and his coworkers1. Hayata et al. investigated photoradiation therapy using an argon dye laser following an intravenous HpD administration in mice, and on cultured human lung cancer cells2, and in experimentally induced canine lung cancer and demonstrated its therapeutic effectiveness3. Malignant bladder tumor were treated by this new technique in this study.

Keywords

Transitional Cell Carcinoma Bladder Carcinoma Quartz Fiber Hematoporphyrin Derivative UICC Classification 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Tetsutaro Ohi
    • 1
  • Harubumi Kato
    • 2
  • Akira Tsuchiya
    • 1
  • Nobuo Obara
    • 1
  • Koichi Imamura
    • 1
  • Katsuo Aizawa
    • 3
  • Chimori Konaka
    • 1
  • Jutaro Ono
    • 2
  • Norihiko Kawate
    • 2
  • Kazuo Yoneyama
    • 2
  • Makoto Saito
    • 2
  • Hidenobu Takahashi
    • 2
  • Sumiyaki Tsukimura
    • 2
  • Hideki Shinohara
    • 2
  • Johnson Lay
    • 2
  • Yoshihiro Hayata
    • 2
  1. 1.Department of UrologyTokyo Medical CollegeShinjuku-ku, Tokyo 160Japan
  2. 2.Department of SurgeryTokyo Medical CollegeShinjuku-ku, Tokyo 160Japan
  3. 3.Department of PhysiologyTokyo Medical CollegeShinjuku-ku, Tokyo 160Japan

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