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Experimental and Clinical Studies on HPD-Photoradiation Therapy for Upper Gastrointestinal Cancer

  • Shigeru Okuda
  • Seishiro Mimura
  • Toru Otani
  • Makoto Ichii
  • Masaharu Tatsuta

Abstract

There have been reports of the use of photosensitizing agents and conventional light source in experimental tumor destruction. In 1972, Diamonds et al. showed that hematoporphyrin was effective as a photosensitizing dye in treatment of animal tumor in vivo. In 1974, Tomson reported the use of acridine orange and aron laser in treatment of mouse epithelial tumors. Recently, Dougherty and Hayata reported success in the clinical treatment of human tumors by using hematoporphyrin derivative and dye laser. In the present paper, we first investigated the phototoxic effect of acridine orange (AO) and hematoporphyrin derivative (HPD) on implanted rat stomach tumor and then reported the clinical results of HPD-photoradiation therapy of the upper gastrointestinal cancers.

Keywords

Gastric Cancer Laser Irradiation Esophageal Cancer Early Gastric Cancer Acridine Orange 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    T. J. Dougherty, J. E. Kaufman, A. Goldfarb, K. R. Weishaupt, D. G. Boyle, and A. Mittleman, Photoradiation therapy for the treatment of malignant tumors, Cancer Res. 28:2628 (1978).Google Scholar
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    S. Okuda, T. Otani, S. Mimura, M. Tatsuda, M. Ichii, H. Mishima, and S. Ishiguro, Application of dye laser to gastroendoscopy, in: “Laser Tokyo ’81”, K. Atsumi and N. Nimsakul, eds., Inter Group Corp., Tokyo (1981).Google Scholar
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    M. Tatsuta, M. Yamamura, R. Yamamoto, M. Ichii, H. Mishima, T. Hattori, and S. Okuda, Photodestruction of rat gastric tumors after acridine orange and argon laser, in: “Laser Tyokyo ’81”, K. Atsumi and N. Mimsakul, eds., Inter Group Corp., Tokyo (1981).Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Shigeru Okuda
    • 1
  • Seishiro Mimura
    • 1
  • Toru Otani
    • 1
  • Makoto Ichii
    • 1
  • Masaharu Tatsuta
    • 1
  1. 1.Department of GastroenterologyThe Center for Adult Diseases, OsakaHigashinari-ku, Osaka 537Japan

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