Experimental and Clinical Studies on HPD-Photoradiation Therapy for Upper Gastrointestinal Cancer
There have been reports of the use of photosensitizing agents and conventional light source in experimental tumor destruction. In 1972, Diamonds et al. showed that hematoporphyrin was effective as a photosensitizing dye in treatment of animal tumor in vivo. In 1974, Tomson reported the use of acridine orange and aron laser in treatment of mouse epithelial tumors. Recently, Dougherty and Hayata reported success in the clinical treatment of human tumors by using hematoporphyrin derivative and dye laser. In the present paper, we first investigated the phototoxic effect of acridine orange (AO) and hematoporphyrin derivative (HPD) on implanted rat stomach tumor and then reported the clinical results of HPD-photoradiation therapy of the upper gastrointestinal cancers.
KeywordsGastric Cancer Laser Irradiation Esophageal Cancer Early Gastric Cancer Acridine Orange
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