Advertisement

Photophysical and Photosensitizing Properties of Photofrin II

  • A. Poletti
  • S. M. Murgia
  • A. Pasqua
  • E. Reddi
  • G. Jori

Abstract

Photofrin II is a newly developed Hematoporphyrin Derivative (Oncology Research & Development), which is widely used in the. phototherapy of tumors owing to its optimal tumor-localizing properties and ability to photosensitize the killing of the tumor cells upon visible light-irradiation1. As known, the mechanism and efficiency of porphyrin photosensitization is dependent on several parameters, including the chemical structure of the porphyrin, its aggregation state and the nature of the micro environment2–5. Therefore, we decided to perform a detailed investigation on the photo-physical and photosensitizing properties of Photofrin II, using experimental conditions which mimic specific situations occurring in vivo.

Keywords

Sodium Dodecyl Sulphate Laser Photolysis Decay Rate Constant Aqueous MeOH MeOH Solution 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bulletin “Photoradiation Technical Information” Jan. 4, 1983, published by Oncology Research & Development Inc., Cheecktowaga, N.Y., the sample was supplied by Prof. T.J. Dougherty.Google Scholar
  2. 2.
    D. Kessel and E. Rossi, Determinations of porphyrin-sensitized photooxidation characterized by fluorescence and absorption spectra, Photochem. Photobiol. 35:83 (1982).CrossRefGoogle Scholar
  3. 3.
    G. Jori, E. Reddi, L. Tomio, and F. Calzavara, Factor governing the mechanism and efficiency of porphyrin-sensitized photooxidations in omogeneous solutions and organized media, in: “Porphyrin Photosensitation”, D. Kessel and T.J. Dougherty, ed., Plenum Press, New York (1983).Google Scholar
  4. 4.
    A. Poletti, S.M’. Murgia, and S. Cannistraro, Laser flash photolysis of the Hematoporphyrin- β carotene system, Photobiochem. Photobiophys. 2:167 (1981).Google Scholar
  5. 5.
    A. Pasqua, A. Poletti, and S.M. Murgia, Ultrafiltration techniques as a tool for the investigation of Hematoporphyrin aggregates in aqueous solution, Med. Biol. Envir. 10:286(1982).Google Scholar
  6. 6.
    S.M. Murgia and A. Poletti, Laser photolysis of methylene blue in aqueous micellar systems, Photobiochem. Photobiophys. 5:53 (1983).Google Scholar
  7. 7.
    E. Rossi, A. Van de Vorst, and G. Jori, Competition between the singlet oxygen and electron transfer mechanism in the porphyrin-sensitized photooxidation of L-tryptophan and tryptamine in aqueous micellar dispersions, Photochem. Photobiol. 34:447 (1981).Google Scholar
  8. 8.
    S.M. Murgia, A. Pasqua, and A. Poletti, Laser flash photolysis studies on Hematoporphyrin IX in aqueous and micellar systems, Med. Biol. Envir. 10:278 (1982).Google Scholar
  9. 9.
    S.M. Murgia, A. Pasqua, and A. Poletti, Laser photolysis study of the Hematoporphyrin IX-L-tryptophan system in solvent mixtures at different polarity, Chem. Phys. Lett. (1983) in press. 10. E. Reddi and M.A. Rodgers, unpublished results.Google Scholar
  10. 10.
    E. Reddi and M. A. Rodgers, unpublished resultsGoogle Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • A. Poletti
    • 1
  • S. M. Murgia
    • 1
  • A. Pasqua
    • 1
  • E. Reddi
    • 1
    • 2
  • G. Jori
    • 1
    • 2
  1. 1.Dipartimento di ChimicaUniversità di PerugiaItaly
  2. 2.Istituto di Biologia AnimaleCentro C.N.R. EmocianinePadovaItaly

Personalised recommendations