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Experimental ENU Induced Brain Tumors with HpD and Dye Laser Light

  • S. Pezzotta
  • G. Spanu
  • R. Cubeddu
  • A. Andreoni
  • M. T. Giordana

Abstract

It is well know that the Hematoporphyrin Derivative (HpD) accumulates preferentially in tumor tissues as compared with the normal tissues (Leonard and Beck, 1971; Lipson et al., 1961; Dougherty et al., 1976).

Keywords

Brain Tumor Laser Treatment Normal Brain Tissue Malignant Brain Tumor Hematoporphyrin Derivative 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Carpenter, R. J. III, Neel, H. B., Ryan, R. J., Sanderson, D. R., 1977, Tumor fluorescence with Hematoporphyrin Derivative, Ann. Otol. Rhinol. Laryngol., 86:661.Google Scholar
  2. Diamond, I., Granelli, S. G., McDonogh, A. F., Nielson, S., Wilson, C. B., Jaenicke, R. , 1972, Photodynamic therapy of malignant tumors, Lancet, 2:1175.CrossRefGoogle Scholar
  3. Dougherty, T. J., Grindey, G. B., Fiel, R. , Weishaupt, K. R., Boyle, D. G., 1975, Photoradiation therapy, II, Cure of animal tumors with Hematoporphyrin and light, J. Nat’l Cancer Inst., 55:115.Google Scholar
  4. Dougherty, T. J., Gomer, C. J., Weishaupt, K. R., 1976, Energetics and efficiency of photoinactivation of murine tumor cells containing Hematoporphyrin, Cancer Res., 36:2330.Google Scholar
  5. Dougherty, T. J., Kaufman, J. E., Goldfarb, A., Weishaupt, K. R., Mittleman, D., Mittleman, A., 1978, Photoradiation therapy for treatment of malignant tumors, Cancer Res., 38:2628.Google Scholar
  6. Gomer, C. J., Dougherty, J. D., 1979, Determination of 3H and 14C Hematoporphyrin Derivative distribution in malignant and normal tissue, Cancer Res., 39:146.Google Scholar
  7. Grossi-Paoletti, E., Paoletti, P., Pezzotta, S., Schiffer, D., Fabiani, A., 1972, Tumors of the nervous system induced by ethylnitrosourea administered either intracerebrally or sub-cutaneously to newborn rats. Morphological and biochemical characteristics, J. Neurosurg., 37:580.Google Scholar
  8. Jori, G., Pizzi, G. B., Reddi, E., Tomio, L., Salvato, B., Zorat, P., Calzavara, F., 1979, Time dependence of Hematoporphyrin distribution in selected tissues of normal rats in ascites hepatoma, Tumori, 65:425.Google Scholar
  9. Laws, E. F. Jr., Cortese, A. N., Kinsey, J. H., Eagan, R. T., Anderson, R. E., 1981, Photoradiation therapy in the treatment of malignant brain tumors: A phase I (feasibility) study, Neurosurg., 9:672.CrossRefGoogle Scholar
  10. Lemberg, R., Legge, J. W., 1949, “Hematin Compounds and Bile Pigments”, Interscience Publishers Inc., New York.Google Scholar
  11. Leonard, J. R., Beck, W. L., 1971, Hematoporphyrin fluorescence: and aid in diagnosis of malignant neoplasm, Laryngoscope, 81:365.CrossRefGoogle Scholar
  12. Lipson, R. L., Baldes, E. J., Olsen, A. M., 1961, The use of a derivative of Hematoporphyrin in tumor detection, J. Nat’l Cancer Inst., 26:1.Google Scholar
  13. Perria, C., Capurso, T., Cavagnaro, G., Datti, R., Francavilla, N., Rivano, C., Tacero, V. E., 1980, First attempt at the photo-dynamic treatment of human gliomas, J. N. Science, 24:119.Google Scholar
  14. Rounds, D. E., Jaques, S., Shelden, C. H., Shaller, C. A., Olson, R. S., 1982, Development of a protocol for photoradiation therapy of malignant brain tumors; Part 1, Neurosurgery, 11:500.CrossRefGoogle Scholar
  15. Schiffer, D., Giordana, M. T., Pezzotta, S., Lechner, C., Paoletti, P., 1978, Cerebral tumors by transplacental ENU; a study of the different tumoral stages, particularly of early neoplastic proliferations, Act. Neuropathol. (Berl), 41:27.CrossRefGoogle Scholar
  16. Schiffer, D., Giordana, M. T., Hauro, A., Racagni, G., Bruno, F., Pezzotta, S., Paoletti, P., 1980, Experimental brain tumors by transplacental ENU. Multi-factorial study of the latency period, Acta Neuropathol. (Berl), 49:117.Google Scholar
  17. Spanu, G., Pezzotta, S., Cubeddu, R., Andreoni, A., Giordana, M. T., 1983, HpD and laser applied to ENU induced brain tumors, Phronesys (in press).Google Scholar
  18. Weishaupt, K. R., Gomer, C. J., Dougherty, T. J., 1976, Identification of singlet oxygen as agent in photo-inactivation of a murine tumor, Cancer Res., 36:2326.Google Scholar
  19. Winkelman, J., Rasmussen-Taxdal, D. S., 1960, Quantitative determination of porphyrin uptake by tumor tissue following parenteral administration, Bull Hopkins Hosp., 107:228.Google Scholar

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • S. Pezzotta
    • 1
  • G. Spanu
    • 1
  • R. Cubeddu
    • 1
    • 2
  • A. Andreoni
    • 1
    • 2
  • M. T. Giordana
    • 1
    • 3
  1. 1.Dipartimento di Chirurgia-Sezione di Clinica NeurochirurgiaUniversità di PaviaItaly
  2. 2.Centro Elettronica Quantistica e Strumentazione ElettronicaCNRMilanoItaly
  3. 3.Clinica Neurologica IIUniversità di TorinoItaly

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