Hematoporphyrin Derivative Phototherapy in Experimental Oncology
Photoradiation therapy is currently under investigation as a new form of treatment for solid malignant tumors in human. The method involves photosensitization of drugs and fluorescent dyes, such as Hematoporphyrin1. This dye has been shown to accumulate with a certain degree of specificity in tissues with a high mitotic index2. Moreover, neoplastic tissue might be identified by the fluorescence emitted from cancerous lesions that have incorporated the dye in larger amounts than normal tissues3. The photodynamic action has implicated singlet oxygen Ca short-lived excited molecular state of ground-state triplet oxygen) as the effective cytotoxic agent4.
KeywordsL1210 Cell Photodynamic Action High Mitotic Index2 Immune Lymphocyte Syngeneic Animal
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