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Effects of HpD and Laser on Transformed and Corresponding Normal Cultured Cells: Differential Cytotoxicity as an in Vitro Model for Tumor Photochemotherapy

  • Francesco Saverio Ambesi-Impiombato
  • Alessandra Andreoni
  • Rinaldo Cubeddu
  • Mario Esposito
  • Michele Mastrocinque
  • Donatella Tramontano

Abstract

In vivo studies on tumor-bearing animals have demonstrated a preferential uptake of several exogenous dyes — and particularly of the Hematoporphyrin-Derivative (HpD) — within the tumor mass 1–4 (reviewed in Ref. 5). Consequently, photoactivation of the dye resulted in selective destruction of the tumor tissue. Such photo-dynamic effects have been utilized in experimental photochemother-apy of induced or spontaneous tumors in animals 3,6–8 After HpD administration, tumor tissues have been irradiated by laser light either directly or through cptic fibres. Success reported with this strategy lead recently to the application of similar protocols to human tumors 9,10.

Keywords

Laser Irradiation Semisolid Medium Photodynamic Effect Cytocidal Effect Differential Cytotoxicity 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Francesco Saverio Ambesi-Impiombato
    • 1
  • Alessandra Andreoni
    • 1
    • 2
  • Rinaldo Cubeddu
    • 1
    • 2
  • Mario Esposito
    • 1
  • Michele Mastrocinque
    • 1
  • Donatella Tramontano
    • 1
  1. 1.Centro di Endocrinologia ed Oncologia Sperimentale del CNR, c/o Istituto di Patologia GeneraleUniversità di NapoliItaly
  2. 2.Centro di Elettronica Quantistica e Strumentazione elettronica del CNRc/o Istituto di Fisica del PolitecnicoMilanoItaly

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