Hematoporphyrin Derivative: Fluorometric Studies in Solution and Cells

  • Giovanni Bottiroli
  • Franco Doccio
  • Isabel Freitas
  • Roberta Ramponi
  • Carlo Alberto Sacchi


Hematoporphyrin Derivative (HpD) is a mixture of porphyrins, widely used in detection and therapy of cancer1,2. HpD was introduced in 1961 by Lipson et al.3 as a better tumor-locating drug than Hematoporphyrin (Hp). They proposed that the crude Hp be treated with a mixture of acetic acid and sulfuric acid, followed by adjustment of the final pH to neutrality. The derivative obtained in such a way is a complex mixture whose chemical composition has yet to be completely clarified. In particular the active components in HpD solution have not been determined. Moreover, many questions about the interaction of this drug with the cellular structures have not been solved.


Hematoporphyrin Derivative Fluorescence Decay Time Primary Fluorescence HAEMATOPORPHYRIN Derivative Soret Region 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Giovanni Bottiroli
    • 1
  • Franco Doccio
    • 1
    • 2
  • Isabel Freitas
    • 1
  • Roberta Ramponi
    • 1
    • 2
  • Carlo Alberto Sacchi
    • 1
    • 2
  1. 1.Centro di studio per l’Istrocimica del CNRIstituto di Anatomia Comparata dell’UniversitàPaviaItaly
  2. 2.Centro di Elettronica Quantistica e Strumentazione, Elettronica del CNRIstituto di Fisica del PolitecnicoMilanoItaly

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