Excited State Properties of Haematoporphyrin
The active component of ‘haematoporphyrin derivative’ (HpD) is probably some aggregate involving both haematoporphyrin (Hp) and hydroxyethylvinyldeuteroporphyrin (HVD) at least as far as selective accumulation in tumours is concerned. Subsequent monomerisation in the cell could occur with the aggregate acting as a ‘pool’ of Hp and HVD so that it is of interest to examine the photophysical properties of such molecules in environments where they may be expected to be monomers as well as in environments where aggregation occurs. In this paper we describe the photophysical properties of Hp in acetone, various detergents, methanol-water mixtures, phosphate buffers and aqueous alkali as well as preliminary results using phosphatidyl choline (PC) vesicles and white blood cells. The major part of the work concerns the study of the lowest excited triplet state of Hp by laser flash photolysis (347 nm excitation).
KeywordsPhosphatidyl Choline Pulse Radiolysis Aqueous Alkali Laser Flash Photolysis Excite State Property
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