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Molecular Induction by Phenobarbital of Cytochrome P-450 and Epoxide Hydrolase

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Genetic Control of Environmental Pollutants

Part of the book series: Basic Life Sciences ((BLSC,volume 28))

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Abstract

Many xenobiotic chemicals, such as pesticides, drugs, and poly-cyclic hydrocarbons, are bioactivated by the microsomal cytochrome P-450-dependent monooxygenases and epoxide hydrolase to oxygenated intermediates which are often highly electrophilic and capable of binding covalently to cellular macromolecules such as DNA.

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Author information

Authors and Affiliations

  1. Department of Environmental Health, SC-34, University of Washington, Seattle, Washington, 98195, USA

    Curtis J. Omiecinski

  2. Eppley Institute for Research in Cancer, University of Nebraska Medical Center, Omaha, Nebraska, 68105, USA

    Edward Bresnick

Authors
  1. Curtis J. Omiecinski
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  2. Edward Bresnick
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Editor information

Editors and Affiliations

  1. University of Washington, Seattle, Washington, USA

    Gilbert S. Omenn

  2. Associated Universities, Inc., Washington, D.C., USA

    Alexander Hollaender

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© 1984 Plenum Press, New York

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Omiecinski, C.J., Bresnick, E. (1984). Molecular Induction by Phenobarbital of Cytochrome P-450 and Epoxide Hydrolase. In: Omenn, G.S., et al. Genetic Control of Environmental Pollutants. Basic Life Sciences, vol 28. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4715-6_31

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  • DOI: https://doi.org/10.1007/978-1-4684-4715-6_31

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-4717-0

  • Online ISBN: 978-1-4684-4715-6

  • eBook Packages: Springer Book Archive

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