Molecular Induction by Phenobarbital of Cytochrome P-450 and Epoxide Hydrolase

  • Curtis J. Omiecinski
  • Edward Bresnick
Part of the Basic Life Sciences book series (BLSC, volume 28)


Many xenobiotic chemicals, such as pesticides, drugs, and poly-cyclic hydrocarbons, are bioactivated by the microsomal cytochrome P-450-dependent monooxygenases and epoxide hydrolase to oxygenated intermediates which are often highly electrophilic and capable of binding covalently to cellular macromolecules such as DNA.


Epoxide Hydrolase Cellular Macromolecule Microsomal Cytochrome Nebraska Medical Cyclic Hydrocarbon 
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Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • Curtis J. Omiecinski
    • 1
  • Edward Bresnick
    • 2
  1. 1.Department of Environmental Health, SC-34University of WashingtonSeattleUSA
  2. 2.Eppley Institute for Research in CancerUniversity of Nebraska Medical CenterOmahaUSA

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