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Evolution of New Degradative Functions for Halogenated Aromatics

  • John J. Kilbane
  • A. M. Chakrabarty
Part of the Basic Life Sciences book series (BLSC, volume 28)

Abstract

The Pseudomonas putida plasmid pAC25 specifies an inducible 3-chlorobenzoic acid degradation pathway. 3-iodobenzoic acid is a poor substrate and fails to induce the enzymes of this pathway, even though 3-fluorobenzoic acid and 3-bromobenzoic acid can both serve as inducers and are good substrates. Through chemostatic selection we have isolated a derivative of pAC25 with altered regulation and substrate specificity such that 3-iodobenzoic acid can now serve as a sole carbon and energy source.

Keywords

Energy Source Substrate Specificity Environmental Pollutant Genetic Control Sole Source 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Plenum Press, New York 1984

Authors and Affiliations

  • John J. Kilbane
    • 1
  • A. M. Chakrabarty
    • 1
  1. 1.Dept. of MicrobiologyUniversity of Illinois at ChicagoChicagoUSA

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