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Human Menopausal Gonadotropins for Follicular Recruitment in In Vitro Fertilization and Embryo Transfer

  • Pedro J. Beauchamp

Abstract

The initiation of follicular development is a continuous process which occurs throughout the menstrual cycle. At the beginning of a new cycle (or in the last few days of the previous cycle) a cohort of those follicles beginning development are recruited to further development by rising levels of follicle stimulating hormone (FSH). These follicles grow to the antral stage and require the continued availability of FSH and Luteinizing Hormone (LH) for further growth and maturation, culminating in ovulation (Fritz and Speroff, 1982). Usually one follicle (seldom more) escapes atresia and is selected to become the dominant, preovulatory follicle (Hodgen, 1982; Chapter 5.) This natural sequence of events is sub-optimal for IVF-ET. The development of multiple preovulatory follicles increases the probability of recovering at least one fertilizable oocyte by laparoscopy (Edwards et al., 1980; Jones et al., 1982).

Keywords

Luteinizing Hormone Pregnancy Rate Granulosa Cell Embryo Transfer Luteal Phase 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Acosta, A.A., Jones, G.S., Sandow, B., Veeck, L., and Mantzavinos, T.H., 1983, Correlation of HMG/HCG stimulation and oocyte quality in an in vitro fertilization program, Fertil. Steril., 39:438.Google Scholar
  2. Ben-Rafael, Z., Dor, J., Mashiach, S., Blankstein, J., Lunenfeld, B., and Serr, D.M., 1983, Abortion rate in pregnancies following ovulation induced by human menopausal gonadotropin/human chorionic gonadotropin, Fertil. Steril., 39:157.PubMedGoogle Scholar
  3. Bergquist, C., Nillius, S.J., and Wide, L., 1983a, Human gonadotropin therapy. I. Serum estradiol and progesterone patterns during conceptual cycles, Fertil. Steril., 39:761.PubMedGoogle Scholar
  4. Bergquist, C., Nillius, S.J., and Wide, L., 1983b, Human gonadotropin therapy. II. Serum estradiol and progesterone patterns during nonconceptual cycles, Fertil. Steril., 39:766.PubMedGoogle Scholar
  5. Buttery, B., Trounson, A., McMaster, R., and Wood, C., 1983, Evaluation of diagnostic ultrasound as a parameter of follicular development in an in vitro fertilization program, Fertil. Steril., 39:458.PubMedGoogle Scholar
  6. Buxton, C.L., 1953, The pitfalls of clinical research, J. Clin. Endocrinol. Metab., 13:231.PubMedCrossRefGoogle Scholar
  7. Edwards, R.G., and Steptoe, P.C., 1975, Induction of follicular growth, ovulation and luteinization in the human ovary, J. Reprod. Fert., 22:121.Google Scholar
  8. Edwards, R.G., Steptoe, P.C., and Purdy, J.M., 1980, Establishing full-term human pregnancies using cleaving embryos grown in vitro, Br. J. Qbstet. Gynecol., 87:737.CrossRefGoogle Scholar
  9. Fritz, M.A., and Speroff, L., 1982, The endocrinology of the menstrual cycle: The interaction of folliculogenesis and neuroendocrine mechanisms, Fertil. Steril., 38:509.PubMedGoogle Scholar
  10. Garcia, J.E., Jones, G.S., Acosta, A.A., and Wright, G., 1983a, Human menopausal gonadotropin/human chorionic gonadotropin follicular maturation for oocyte aspiration: Phase I, 1981. Fertil. Steril., 39:167.PubMedGoogle Scholar
  11. Garcia, J.E., Jones, G.S., Acosta, A.A., and Wright, G., 1983b, Human menopausal gonadotropin/human chorionic gonadotropin follicular maturation for oocyte aspiration: Phase II, 1981. Fertil. Steril., 39:174.Google Scholar
  12. Garcia, J.E., Acosta, A., and Jones, H.W., 1983c, Advanced endometrial maturation after ovulation induction with HMG/HCG for in vitro fertilization, Fertil. Steril., 39: 426.Google Scholar
  13. Gemzell, C.A., Diczfalusy, E., and Tillinger, K.G., 1958, Clinical effect of human pituitary follicle stimulating hormone, J. Clin. Endocrinol. Metab., 18:1333.PubMedCrossRefGoogle Scholar
  14. Haning, R., Austin, C.W., Kuzma, D.L., Shapiro, S.S., and Zweibel, W.J., 1982, Ultrasound evaluation of estrogen monitoring for induction of ovulation with menotropins, Fertil. Steril., 37:627.PubMedGoogle Scholar
  15. Hodgen, G.D., 1982, The dominant ovarian follicle, Fertil. Steril., 38:281.PubMedGoogle Scholar
  16. Insler, V., and Potashnik, G., 1983, Monitoring of follicular development in gonadotropin-stimulated cycles, in: “Fertilization of the Human Egg In Vitro”. H.M. Beier and H.R. Lindner, eds., Springer-Verlag Publishers, Berlin.Google Scholar
  17. Jones, H.W., Jones, G.S., Andrews, M.C., Acosta, A., Bundren, C., Garcia, J., Sandow, B., Veeck, L., Wilkes, C., Witmyer, J., Wortham, J.E., and Wright, G., 1982, The program for In vitro fertilization at Norfolk, Fertil. Steril., 38:14.PubMedGoogle Scholar
  18. Jones, H.W., Acosta, A.A., Garcia, J.E., Sandow, B.A., and Veeck, L., 1983a, On the transfer of conceptuses from oocytes fertilized in vitro, Fertil. Steril., 39:241.Google Scholar
  19. Jones, H.W., Acosta, A., Andrews, M.C., Garcia, J.E., Jones, G.S., Mantzavinos, T.H., McDowell, J., Sandow, B., Veeck, L., Whibley, T., Wilkes, C., and Wright, G., 1983b, The importance of the follicular phase to success and failure in in vitro fertilization, Fertil. Steril., 40:317.Google Scholar
  20. Johnston, I., Lopata, A., Spiers, A., Hoult, I., Kellow, G., and Du Plessis, Y., 1981, In vitro fertilization: The challenge of the eighties, Fertil. Steril., 36:699.PubMedGoogle Scholar
  21. Johnston, I.W.H., 1983, Discussion of Vargyas, J. M. Saito, H. Gibbons, W. E. Sueldo, C. Yee W. and Marrs, R.P., Effects of different methods of ovarian stimulation on the human in vitro fertilization and embryo transfer procedure, presented at 39th Annual Meeting of the American Fertility Society, April 16–20, 1983, San Francisco, CA.Google Scholar
  22. Kerin, J.F., Warnes, G.M., Quinn, P.J., Jeffrey, R., Kirby, C., Matthews, C.D., Seamark, R.F., and Cox, L.W., 1983, Incidence of multiple pregnancy following human in vitro fertilization and embryo transfer, Lancet, 2:537.PubMedCrossRefGoogle Scholar
  23. Lopata, A., Johnston, I.W.H., Hoult, I.J., and Speirs, A.L., 1980, Pregnancy following intrauterine implantation of an embryo obtained by in vitro fertilization of a preovulatory egg, Fertil. Steril., 33:117.PubMedGoogle Scholar
  24. Lopata, A., 1983, Concepts in human in vitro fertilization and embryo transfer, Fertil. Steril., 40:289.PubMedGoogle Scholar
  25. Lunenfeld, B., Menzi, A., and Valet, B., 1960, Clinical effects of a human post menopausal gonadotropin, Ross. Clin. Ter. Sci. Affini., 59:213.Google Scholar
  26. Mantzavinos, T.H., Garcia, J.E., and Jones, H.W., 1983, Follicular ultrasound measurement in human gonadotropin ovulation induction patients for in vitro fertilization, Fertil. Steril., 39:415.Google Scholar
  27. Olson, J.L., Rebar, R.W., Schreiber, J.R., and Vaitukaitis, J.L., 1983, Shortened luteal phase after ovulation induction with human menopausal gonadotropin and human chorionic gonadotropin, Fertil. Steril., 39:284.PubMedGoogle Scholar
  28. Quigley, M.M., Schmidt, C.L., Beauchamp, P.J., Pace-Owens, S., and Wolf, D.P., 1984, Menopausal gonadotropins compared to clomiphene citrate for enhanced follicular recruitment in an in vitro fertilization program, Fertil. Steril., (in press).Google Scholar
  29. Renaud, R., Macler, J., Ehret, M.C., Aron, C., Plas-Roser, S., Spira, A., and Pollack, H., 1983, Echographic study of follicular maturation and ovulation during the normal menstrual cycle, Fertil. Steril., 33:272.Google Scholar
  30. Schenker, J.G., and Weinstein, D., 1978, Ovarian hyperstimulation syndrome: a current survey, Fertil. Steril., 30:255.PubMedGoogle Scholar
  31. Schenker, J.G., Yarkoni, S., and Granat, M., 1981, Multiple pregnancies following induction of ovulation, Fertil. Steril., 35:105.PubMedGoogle Scholar
  32. Schwartz, M., and Jewelewicz, R., 1981, The use of gonadotropins for induction of ovulation, Fertil. Steril., 35:3.PubMedGoogle Scholar
  33. Spiers, A.L., Lopata, A., Gronow, M.J., Kellow, G.N., and Johnston, I.W.H., 1983, Analysis of benefits and risks of multiple embryo transfer, Fertil. Steril., 39:468.Google Scholar
  34. Steptoe, P.C., Edwards, R.G., and Purdy, J.M., 1980, Clinical aspects of pregnancies established with cleaving embryos grown in vitro, Br. J. Obstet. Gynecol., 87:757.CrossRefGoogle Scholar
  35. Vargyas, J.M., Saito, H., Gibbons, W.E., Sueldo, C., Yee, W., and Marrs, R.P., 1983, Effect of different methods of ovarian stimulation on the human in vitro fertilization and embryo transfer procedure, Fertil. Steril., 39:438.Google Scholar
  36. Wood, C., Trounson A., Leeton, J., Talbot, J. McK., Buttery, B., Webb, J., Wood, J., and Jessup, D., 1981, A clinical assessment of nine pregnancies obtained by in vitro fertilization and embryo transfer, Fertil. Steril., 35:502.PubMedGoogle Scholar
  37. Wortham, J.W.E., Veeck, L.L., Witmyer, J., and Jones, H.W., 1983, Vital initiation of pregnancy (VIP) using human menopausal gonadotropin and human chorionic gonadotropin ovulation induction: Phase I, 1981, Fertil. Steril., 39:785.PubMedGoogle Scholar
  38. Yuen, B.J., Sy, L., and Cannon, W., 1981, Regulation of ovarian follicular and luteal function during treatment with exogenous gonadotropins in anovulatory infertility, Am. J. Obstet. Gynecol., 140:629.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1984

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  • Pedro J. Beauchamp

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