Abstract
Since 1952 the antiviral activity of benzimidazoles has been studied extensively (1). A major stimulus during this work has been the central finding that virus-inhibiting activity and cell toxicity of chemical derivatives of benzimidazoles may vary independently (2). The introduction of 2-(α-hydroxybenzyl)-benzimidazole (HBB) as an antiviral agent marked a most important step of the investigations on selective inhibition of viral replication (3,4). It was found that HBB inhibits multiplication of poliovirus 2 in monkey kidney cell culture at concentrations which caused no microscopic changes in the cells. On the other hand, influenza virus multiplication remained unaffected (4).
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Eggers, H.J. (1984). Antiviral Action of 2-(α-Hydroxybenzyl)-Benzimidazole (HBB). In: De Clercq, E., Walker, R.T. (eds) Targets for the Design of Antiviral Agents. NATO ASI Series, vol 73. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-4709-5_8
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DOI: https://doi.org/10.1007/978-1-4684-4709-5_8
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