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Picornaviruses and Togaviruses: Targets for Design of Antivirals

  • Bruce D. Korant
  • Karl Lonberg-Holm
  • Paolo Lacolla
Part of the NATO ASI Series book series (NSSA, volume 73)

Abstract

The picornaviruses and togaviruses are important pathogens in man and some other animal species. Human infections caused by picornaviruses are found in all geographical regions and climates. The prototype of the group are the polioviruses, causitive agents of poliomyelitis, a devastating disease of the central nervous system. Thirty or more years ago poliovirus epidemics caused paralytic disease in thousands of children and young adults, especially among the middle and upper class of Western countries. The terrifying nature of these epidemics helped launch high visibility, public-funded animal virology research in the U.S. and western Europe. Today the fruits of that support are visible; the picornaviruses are among the best understood of all viruses at the biochemical level. Togaviruses are usually arthropod borne but they are not limited to tropical regions. Their infections are often subclinical but sometimes lead to encephalitides and hemorrhagic fevers which rank among the most lethal of all virus diseases.

Keywords

Crown Ether Envelope Protein Semliki Forest Virus Minus Strand Human Rhinovirus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Bruce D. Korant
    • 1
  • Karl Lonberg-Holm
    • 1
  • Paolo Lacolla
    • 2
  1. 1.Central Research & Development DepartmentE. I. du Pont de Nemours & CompanyWilmingtonUSA
  2. 2.Department of Microbiology, Virology InstituteUniversity of CagliariSardiniaItaly

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