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Strategies in the Design of Oligonucleotides as Potential Antiviral Agents

  • Paul F. Torrence
  • Jiro Imai
  • Krystyna Lesiak
  • Jean-Claude Jamoulle
  • Hiroaki Sawai
  • Johan Warinnier
  • Jan Balzarini
  • Erik De Clercq
Part of the NATO ASI Series book series (NSSA, volume 73)

Abstract

Polynucleotides have enjoyed considerable success as antiviral or antitumor agents due to their interferon-inducing ability1,2, their immunoadjuvant activity3, their reverse-transcriptase inhibitor properties4 or their capacity to inhibit virion-associated transcriptases5. On the other hand, the small sequence-defined oligonucleotides, until recently, have attracted little interest in this regard. Nonetheless, the potential of oligonucleotides as chemotherapeutic agents has been long appreciated. Levene and Stollar6 obtained partial inhibition of systemic lupus erythematosus sera by tetra- and pentanucleotides, and Shen7 suggested the design of high affinity oligonucleotide inhibitors of antigen-antibody complex formation. Oligonucleotides also have been employed as prodrug forms8, but we will not deal with this particular application.

Keywords

Phosphodiester Bond Interferon Treatment Rabbit Reticulocyte Lysate Severe Combine Immunodeficiency Disease Globin mRNA 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1984

Authors and Affiliations

  • Paul F. Torrence
    • 1
  • Jiro Imai
    • 1
  • Krystyna Lesiak
    • 1
  • Jean-Claude Jamoulle
    • 1
  • Hiroaki Sawai
    • 2
  • Johan Warinnier
    • 3
  • Jan Balzarini
    • 3
  • Erik De Clercq
    • 3
  1. 1.Laboratory of Chemistry, National Institute of Arthritis, Diabetes and Digestive and Kidney DiseasesU.S. National Institutes of HealthBethesdaUSA
  2. 2.Faculty of Pharmaceutical SciencesUniversity of TokyoBunkyo-ku, TokyoJapan
  3. 3.Rega InstituteUniversity of LeuvenLeuvenBelgium

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